Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 3/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 4/20 | 0.44 |
| ▸ | PPARA | Q07869 | 4/20 | 0.44 |
| ▸ | PPARD | Q03181 | 3/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | BCL2 | P10415 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9056875 | 0.86 | HTR6 (0.55) | HTR6BCHECNR2L3MBTL1 | |
| SCHEMBL8387014 | 0.81 | MPO (0.55) | MPOMAOBMAPK14FAAHPPARG | |
| SCHEMBL8389282 | 0.80 | HTR6 (0.48) | HTR6BCHEPPARGPPARA | |
| SCHEMBL6085083 | 0.77 | HTR6 (0.44) | HTR6CNR2MCL1MAPT | |
| SCHEMBL18049242 | 0.76 | HTR6 (0.67) | HTR6MAPK14CNR2BCL2MCL1 | |
| SCHEMBL8388912 | 0.76 | CNR1 (0.45) | HTR6CNR2MCL1MAPT | |
| SCHEMBL8390685 | 0.74 | DYRK1A (0.50) | MAOBFAAHPPARGPPARAPPARD | |
| SCHEMBL5746820 | 0.73 | MAOB (0.68) | MAOBNR4A2SRD5A2 | |
| SCHEMBL27657235 | 0.73 | KMT2A (0.49) | MAOBHTR6PPARGMAPT | |
| SCHEMBL27498565 | 0.73 | MTNR1A (0.41) | MAOBHTR6BCHEMAPK14BCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5877199-A | ALZHEIMER'S DISEASE; SEDATIVE | SANKYO COMPANY, LIMITED (JP) | 1999-03-02 | — | — | US | disclosed |
| CN-1166169-A | Heterocyclic compounds, useful as allosteric effectors at muscarinic receptors | SANKYO CO (JP) | 1997-11-26 | — | — | CN | disclosed |
| WO-1996003377-A1 | HETEROCYCLIC COMPOUNDS, USEFUL AS ALLOSTERIC EFFECTORS AT MUSCARINIC RECEPTORS | SANKYO COMPANY, LIMITED (JP) | 1996-02-08 | — | — | WO | disclosed |