SCHEMBL8387692

SCHEMBL8387692

COc1ccccc1CN(C)CCOc1cccc(Cl)c1CN(C)C

nearest known ligand 0.52

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 3/20 0.52
SLC6A2 P23975 2/20 0.47
SLC6A4 P31645 2/20 0.47
SLC6A3 Q01959 2/20 0.47
TP53 P04637 1/20 0.47
CARM1 Q86X55 1/20 0.46
BCHE P06276 4/20 0.45
MAOB P27338 3/20 0.44
HTR7 P34969 1/20 0.44
ACHE P22303 2/20 0.43
CHRM1 P11229 1/20 0.43
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
HTR1D P28221 1/20 0.41
HTR1B P28222 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8388817 0.87 CARM1 (0.43) CHRM2SLC6A2SLC6A4SLC6A3CARM1
SCHEMBL8392079 0.84 HTR1D (0.60) HTR1DHTR1B
Hydrochloric Acid SCHEMBL8743607 0.82 HTR1D (0.59) HTR1DHTR1B
SCHEMBL8387461 0.82 SLC6A2 (0.57) CHRM2SLC6A2SLC6A4SLC6A3CARM1
SCHEMBL8388824 0.78 LMNA (0.60) KMT2AHTR1DHTR1B
Hydrochloric Acid SCHEMBL8743690 0.74 DRD3 (0.42) SLC6A2SLC6A4SLC6A3TP53BCHE
SCHEMBL3894485 0.73 HTR7 (0.59) CHRM2SLC6A2SLC6A4SLC6A3CARM1
SCHEMBL8392132 0.72 HTR1D (0.59) CARM1HTR1DHTR1B
Hydrochloric Acid SCHEMBL8743625 0.72 DRD2 (0.48) TP53BCHEMAOBHTR1DHTR1B
SCHEMBL8387614 0.72 CARM1 (0.58) SLC6A2SLC6A4SLC6A3CARM1HTR1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0750607-B1 2-(AMINOALKOXY)PHENYLALKYLAMINES WITH ANTIINFLAMMATORY ACTIVITY KNOLL AG (DE) 1999-05-06 EP disclosed
US-5736568-A ANTIALLERGENS; IMMUNOMODULANTS KNOLL AKTIENGESELLSCHAFT (DE) 1998-04-07 US disclosed
EP-0750607-A1 2-(AMINOALKOXY)PHENYLALKYLAMINES WITH ANTIINFLAMMATORY ACTIVITY Knoll AG (DE) 1997-01-02 EP disclosed
WO-1995023127-A1 2-(AMINOALKOXY)PHENYLALKYLAMINES WITH ANTIINFLAMMATORY ACTIVITY KNOLL AG (DE) 1995-08-31 WO disclosed