Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ACP1 | P24666 | 2/20 | 0.39 |
| ▸ | ALDH1A3 | P47895 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.34 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | CLK3 | P49761 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL840596 | 0.83 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2HTTACP1ALDH1A3 | |
| SCHEMBL31193388 | 0.73 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2HTTALDH1A3KDM4E | |
| SCHEMBL839781 | 0.72 | ENPP2 (0.41) | ALDH1A1HTTACP1HRH3 | |
| SCHEMBL838762 | 0.68 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2HTTKDM4EHRH3 | |
| SCHEMBL13038380 | 0.68 | KDM4E (0.48) | ALDH1A1SMN1; SMN2ALDH1A3KDM4EHRH3 | |
| SCHEMBL19634167 | 0.67 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2HTTKDM4EHRH3 | |
| SCHEMBL1873733 | 0.67 | ALDH1A1 (0.97) | ALDH1A1SMN1; SMN2HTTALDH1A3KDM4E | |
| SCHEMBL29728056 | 0.67 | ALDH1A1 (0.97) | ALDH1A1SMN1; SMN2HTTALDH1A3KDM4E | |
| SCHEMBL6852399 | 0.66 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2ALDH1A3KDM4E | |
| SCHEMBL15264110 | 0.66 | ALDH1A1 (0.77) | ALDH1A1SMN1; SMN2HTTALDH1A3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143246-B2 | 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivatives | MSD OSS B.V. (NL) | 2012-03-27 | — | — | US | disclosed |
| US-20100144724-A1 | 1-(4-(PYRIDIN-2-YL)BENZYL)IMIDAZOLIDINE-2,4-DIONE DERIVATIVES | N.V.ORGANON | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144724-A1 | 1-(4-(PYRIDIN-2-YL)BENZYL)IMIDAZOLIDINE-2,4-DIONE DERIVATIVES | OPRD1, CNR1, CNR2 | ALDH1A1 3782/4885SMN1; SMN2 87/4885HTT 2261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.