Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CLK3 | P49761 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | ACP1 | P24666 | 2/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL838858 | 0.83 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2CLK2CLK3DYRK1A | |
| SCHEMBL839479 | 0.80 | CYP2D6 (0.42) | ALDH1A1SMN1; SMN2CXCR4SCN9APARP1 | |
| SCHEMBL840636 | 0.76 | ACP1 (0.39) | ALDH1A1ACP1SCN9AFLT3TYRO3 | |
| SCHEMBL839660 | 0.75 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2CXCR4CLK2CLK3 | |
| SCHEMBL18157904 | 0.70 | CXCR4 (0.66) | ALDH1A1SMN1; SMN2CXCR4HTTKDM4E | |
| SCHEMBL8305165 | 0.70 | CXCR4 (0.49) | ALDH1A1SMN1; SMN2CXCR4ERN1KDM4E | |
| SCHEMBL31497604 | 0.70 | KIF11 (0.40) | ALDH1A1SMN1; SMN2 | |
| Bromide SCHEMBL29605492 | 0.69 | CXCR4 (0.63) | ALDH1A1SMN1; SMN2CXCR4HTTKDM4E | |
| Hydrochloric Acid SCHEMBL29604003 | 0.69 | CXCR4 (0.63) | ALDH1A1SMN1; SMN2CXCR4HTTKDM4E | |
| SCHEMBL31193388 | 0.69 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2ALDH1A3HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143246-B2 | 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivatives | MSD OSS B.V. (NL) | 2012-03-27 | — | — | US | disclosed |
| US-20100144724-A1 | 1-(4-(PYRIDIN-2-YL)BENZYL)IMIDAZOLIDINE-2,4-DIONE DERIVATIVES | N.V.ORGANON | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144724-A1 | 1-(4-(PYRIDIN-2-YL)BENZYL)IMIDAZOLIDINE-2,4-DIONE DERIVATIVES | OPRD1, CNR1, CNR2 | ALDH1A1 3782/4885SMN1; SMN2 87/4885CXCR4 473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.