Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 18/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.41 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8384904 | 0.98 | PTGS2 (0.44) | PTGS2PTGS1GHSRPTGDR2 | |
| SCHEMBL8387622 | 0.96 | PTGS2 (0.45) | PTGS2PTGS1GHSRPTGDR2 | |
| SCHEMBL8388576 | 0.90 | PTGS2 (0.43) | PTGS2PTGS1GHSR | |
| SCHEMBL8387842 | 0.86 | PTGS2 (0.41) | PTGS2PTGS1GHSR | |
| SCHEMBL8388744 | 0.83 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL8383896 | 0.81 | PTGS2 (0.65) | PTGS2PTGS1 | |
| SCHEMBL8386008 | 0.81 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL8388609 | 0.79 | PTGS2 (0.44) | PTGS2PTGS1 | |
| SCHEMBL8384013 | 0.78 | PTGS2 (0.65) | PTGS2PTGS1 | |
| SCHEMBL9115540 | 0.78 | GHSR (0.37) | PTGS2PTGS1GHSRPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743938-B1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 1999-04-21 | — | — | EP | disclosed |
| EP-0743938-A1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-27 | — | — | EP | disclosed |
| WO-1995021817-A1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-08-17 | — | — | WO | disclosed |
| US-5393790-A | Diphenyl- or phenyl/pyridyl-substituted spiroheptenes, -octenes,-nonenes or -decenes; cyclooxygenase II inhibitors; side effect reduction; antipyretics; antiarthritic agents | G.D. SEARLE & CO. (US) | 1995-02-28 | — | — | US | disclosed |