Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 3/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 3/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL8396187 | 0.98 | GAA (0.44) | GAARAB9ASMN1; SMN2NPC1HTT | |
| SCHEMBL8392170 | 0.89 | NAMPT (0.43) | RAB9ASMN1; SMN2NPC1NAMPTROCK2 | |
| Oxalic Acid SCHEMBL8392856 | 0.87 | HRH3 (0.42) | SMN1; SMN2NPC1NAMPTROCK2ROCK1 | |
| SCHEMBL8525511 | 0.81 | NAMPT (0.57) | GAARAB9ANPC1NAMPT | |
| SCHEMBL8392369 | 0.79 | POLB (0.41) | RAB9ASMN1; SMN2NPC1MEN1MAPT | |
| SCHEMBL8393077 | 0.78 | POLB (0.47) | GAARAB9ASMN1; SMN2NPC1NAMPT | |
| Bromide SCHEMBL8394207 | 0.77 | POLB (0.46) | GAARAB9ASMN1; SMN2NPC1NAMPT | |
| SCHEMBL8392137 | 0.77 | TPSAB1 (0.51) | GAARAB9ASMN1; SMN2NPC1HTT | |
| SCHEMBL8392843 | 0.76 | MAPT (0.62) | GAARAB9ASMN1; SMN2NPC1HTT | |
| SCHEMBL8392001 | 0.76 | NPC1 (0.46) | RAB9ASMN1; SMN2NPC1NAMPTNAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690851-B1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AB (SE) | 1999-05-19 | — | — | EP | claimed |
| US-5885985-A | Guanidine derivatives useful in therapy | ASTRA AKTIEBOLAG (SE) | 1999-03-23 | — | — | US | claimed |
| EP-0690851-A1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | Astra Aktiebolag (SE) | 1996-01-10 | — | — | EP | claimed |
| WO-1994021621-A1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AKTIEBOLAG (SE) | 1994-09-29 | — | — | WO | claimed |