Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL8392856 | 0.98 | HRH3 (0.42) | NAMPTCHRM1HTR2AMCHR1ALDH1A1 | |
| SCHEMBL8392136 | 0.89 | GAA (0.46) | NAMPTMAPTHRH3SMN1; SMN2ROCK2 | |
| SCHEMBL8392369 | 0.88 | POLB (0.41) | ALDH1A1MAPTPOLBSMN1; SMN2NPC1 | |
| Oxalic Acid SCHEMBL8396187 | 0.87 | GAA (0.44) | NAMPTALDH1A1HRH3SMN1; SMN2ROCK2 | |
| SCHEMBL8396226 | 0.80 | ALDH1A1 (0.56) | NAMPTALDH1A1MAPTTP53ROCK2 | |
| SCHEMBL8392174 | 0.76 | TPSAB1 (0.53) | — | |
| SCHEMBL8393077 | 0.75 | POLB (0.47) | NAMPTCHRM1HTR2AMCHR1ALDH1A1 | |
| SCHEMBL29221819 | 0.75 | HSP90AA1 (0.53) | ALDH1A1MAPTL3MBTL1SMN1; SMN2KMT2A | |
| Bromide SCHEMBL8394207 | 0.74 | POLB (0.46) | NAMPTCHRM1HTR2AMCHR1ALDH1A1 | |
| SCHEMBL9218989 | 0.74 | MEN1 (0.45) | NAMPTALDH1A1MAPTL3MBTL1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690851-B1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AB (SE) | 1999-05-19 | — | — | EP | claimed |
| US-5885985-A | Guanidine derivatives useful in therapy | ASTRA AKTIEBOLAG (SE) | 1999-03-23 | — | — | US | claimed |
| EP-0690851-A1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | Astra Aktiebolag (SE) | 1996-01-10 | — | — | EP | claimed |
| WO-1994021621-A1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AKTIEBOLAG (SE) | 1994-09-29 | — | — | WO | claimed |