Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.55 |
| ▸ | CTSD | P07339 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2497266 | 0.97 | ALDH1A1 (0.52) | ALDH1A1TDP1CTSDMAPTCYP3A4 | |
| Bromide SCHEMBL28378200 | 0.97 | ALDH1A1 (0.52) | ALDH1A1TDP1CTSDMAPTCYP3A4 | |
| Oxalic Acid SCHEMBL28377528 | 0.89 | GAA (0.48) | ALDH1A1TDP1CTSDMAPTCYP3A4 | |
| SCHEMBL7408731 | 0.75 | PTGS2 (0.41) | ALDH1A1MAPTCYP3A4GAAALOX12 | |
| SCHEMBL5397882 | 0.74 | TDP1 (0.55) | ALDH1A1TDP1CTSDMAPTCYP3A4 | |
| Hydrazobenzene SCHEMBL51179 | 0.73 | ALDH1A1 (1.00) | ALDH1A1TDP1CTSDMAPTCYP3A4 | |
| SCHEMBL19737269 | 0.73 | ALDH1A1 (1.00) | ALDH1A1TDP1CTSDMAPTCYP3A4 | |
| SCHEMBL412378 | 0.72 | ALDH1A1 (0.45) | ALDH1A1TDP1CTSDMAPTCYP3A4 | |
| SCHEMBL9172014 | 0.72 | ALDH1A1 (0.52) | ALDH1A1TDP1CTSDMAPTCYP3A4 | |
| Fluoride SCHEMBL5178837 | 0.70 | ALDH1A1 (0.43) | ALDH1A1TDP1CTSDMAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118852082-A | Flavonol derivative containing hydrazide active fragment and application thereof | 南京农业大学 | 2024-10-29 | — | — | CN | disclosed |
| CN-114634442-B | Preparation method of tetrahydrocarbazolone compound | 内蒙古民族大学 | 2023-10-13 | — | — | CN | disclosed |
| WO-2022040157-A1 | BORON CONTAINING COMPOUNDS AND THEIR USES | 5METIS, INC. (US) | 2022-02-24 | — | — | WO | disclosed |
| CN-108586527-B | Aryl phosphonate compound and preparation method thereof | 郑州大学 | 2020-03-31 | — | — | CN | disclosed |
| CN-108586527-A | Arylphosphonic acid ester type compound and preparation method thereof | 郑州大学 | 2018-09-28 | — | — | CN | disclosed |
| EP-2268623-B9 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORP (US) | 2018-02-28 | — | — | EP | disclosed |
| CN-107663161-A | A kind of continuous stream synthesis technique of phenylhydrazine salt and substituted benzene hydrazonium salt | 上海惠和化德生物科技有限公司 | 2018-02-06 | — | — | CN | disclosed |
| US-9730937-B2 | RAF kinase modulator compounds and methods of use thereof | AMBIT BIOSCIENCES CORPORATION (US) | 2017-08-15 | — | — | US | disclosed |
| EP-3147281-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2017-03-29 | — | — | EP | disclosed |
| CN-106146484-A | Quinazoline derivant is as RAF kinase modulator and their method and purposes | 埃姆比特生物科学公司 | 2016-11-23 | — | — | CN | disclosed |
| US-20070049632-A1 | Pyrazolones as inhibitors of 11B-hydroxysteroid dehydrogenase | BANNER BRUCE L | 2007-03-01 | — | — | US | disclosed |
| CN-1865248-A | Imidazole-4-carboxamide derivatives, preparation and use thereof for treatment of obesity | BAYER PHARMACEUTICALS CORP (US) | 2006-11-22 | — | — | CN | disclosed |
| US-20060135712-A1 | Ethylened polymer and molded object obtained therefrom | MITSUI CHEMICALS, INC. (JP) | 2006-06-22 | — | — | US | disclosed |
| US-20060106013-A1 | PI3-kinases | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-05-18 | — | — | US | disclosed |
| CN-1642879-A | Process for preparing diaryl compounds | SUMITOMO CHEMICAL CO (JP) | 2005-07-20 | — | — | CN | disclosed |
| CN-1599724-A | Imidazole-4-carboxamide derivatives, their preparation and use in the treatment of obesity | BAYER PHARMACEUTICALS CORPORAT (US) | 2005-03-23 | — | — | CN | disclosed |
| CN-1043766-C | Indole derivative and preparation and pharmaceutical using of same | TORAY INDUSTRIES (JP) | 1999-06-23 | — | — | CN | disclosed |
| CN-1092425-A | Indole derivatives, its manufacture method and medicinal use thereof | TORAY INDUSTRIES (JP) | 1994-09-21 | — | — | CN | disclosed |
| US-5051417-A | Indolythiadiazines for treating heart failure | LES LABORATOIRES BEECHAM S.A. (FR) | 1991-09-24 | — | — | US | disclosed |
| EP-0351213-A2 | 2-Indolones substituted in 5 by a cyclic hydrazide radical, their preparation and their use in cardio-active medicaments | LES LABORATOIRES BEECHAM S.A. (FR) | 1990-01-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049632-A1 | Pyrazolones as inhibitors of 11B-hydroxysteroid dehydrogenase | HSD17B1, HSD17B2, HSD3B2 | ALDH1A1 105/4885TDP1 1844/4885CTSD 3617/4885 |
| US-20060106013-A1 | PI3-kinases | PIK3C3, PIK3CB, PIK3CD | ALDH1A1 1935/4885TDP1 3518/4885CTSD 1952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.