SCHEMBL8392948

SCHEMBL8392948

COc1cc(/C=C/C(=O)CCCCc2ccccc2)cc(OC)c1O

nearest known ligand 0.84

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ ALOX5 P09917 11/20 0.84
▸ MET P08581 3/20 0.57
▸ PKM P14618 1/20 0.55
▸ PTGS1 P23219 1/20 0.55
▸ PTGS2 P35354 1/20 0.55
▸ APP P05067 1/20 0.54
▸ MAPT P10636 1/20 0.54
▸ TTR P02766 1/20 0.54
▸ ALDH1A1 P00352 2/20 0.53
▸ KDM4E B2RXH2 1/20 0.53
▸ CYP1A2 P05177 1/20 0.52
▸ CYP3A4 P08684 1/20 0.52
▸ CYP2D6 P10635 1/20 0.52
▸ CYP2C9 P11712 1/20 0.52
▸ CYP2B6 P20813 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8392953 1.00 ALOX5 (0.84) ALOX5METPKMPTGS1PTGS2
SCHEMBL17833497 0.93 ALOX5 (0.74) ALOX5METPTGS1APPMAPT
SCHEMBL10467072 0.91 ALOX5 (1.00) ALOX5METPKMPTGS1PTGS2
SCHEMBL10467071 0.91 ALOX5 (1.00) ALOX5METPKMPTGS1PTGS2
SCHEMBL3686080 0.89 ALOX5 (1.00) ALOX5METPKMPTGS1PTGS2
SCHEMBL30219096 0.89 ALOX5 (1.00) ALOX5METPKMPTGS1PTGS2
SCHEMBL9533683 0.89 ALOX5 (1.00) ALOX5METPKMPTGS1PTGS2
SCHEMBL29489703 0.88 ALOX5 (0.84) ALOX5APPMAPTTTRALDH1A1
SCHEMBL29489695 0.87 ALOX5 (0.83) ALOX5APPMAPTTTRALDH1A1
SCHEMBL9534542 0.87 ALOX5 (0.83) ALOX5APPMAPTTTRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116650898-B Application of over-expressed alkane hydroxylase gene and laccase gene in LDPE degradation 天津大学 2024-06-25 — — CN disclosed
CN-118028291-A Application of over-expressed alkane hydroxylase gene and laccase gene in LDPE degradation 天津大学 2024-05-14 — — CN disclosed
CN-116650898-A Application of over-expressed alkane hydroxylase gene and laccase gene in LDPE degradation 天津大学 2023-08-29 — — CN disclosed
US-20160166508-A1 Method and Composition for Treating Inflammatory Disorders MEDA AB (SE) 2016-06-16 — — US disclosed
US-20090220583-A1 Method and composition for treating inflammatory disorders MEDA AB (SE) 2009-09-03 — — US disclosed
US-20090220583-A1 Method and composition for treating inflammatory disorders MEDA AB (SE) 2009-09-03 — — US disclosed
US-20080081835-A1 Use of Ltb4 Inhibitors for the Treatment of B-Cell Leukemias and Lymphomas BIOLIPOX AB (SE) 2008-04-03 — — US disclosed
US-20080081835-A1 Use of Ltb4 Inhibitors for the Treatment of B-Cell Leukemias and Lymphomas BIOLIPOX AB (SE) 2008-04-03 — — US disclosed
EP-0717027-B1 Diarylheptanoide derivative and pharmaceutical composition comprising the same YAKULT HONSHA KK (JP) 1999-05-12 — — EP disclosed
US-5763673-A ENZYME INHIBITORS AND ANTIINFLAMMATORY AGENTS KABUSHIKI KAISHA YAKULT HONSHA (JP) 1998-06-09 — — US disclosed
EP-0717027-A1 Diarylheptanoide derivative and pharmaceutical composition comprising the same KABUSHIKI KAISHA YAKULT HONSHA (JP) 1996-06-19 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090220583-A1 Method and composition for treating inflammatory disorders LIPA, HRH2, HRH1 ALOX5 25/4885MET 4664/4885PKM 3198/4885
US-20160166508-A1 Method and Composition for Treating Inflammatory Disorders LIPA, HRH2, HRH1 ALOX5 25/4885MET 4664/4885PKM 3198/4885
US-20080081835-A1 Use of Ltb4 Inhibitors for the Treatment of B-Cell Leukemias and Lymphomas LTB4R, LTA4H, LTA ALOX5 10/4885MET 4203/4885PKM 1272/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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