Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9179158 | 0.83 | ALDH1A1 (0.50) | ALDH1A1TDP1L3MBTL1MAPK1SLC6A2 | |
| SCHEMBL8392747 | 0.83 | HCAR2 (0.49) | ALDH1A1TDP1L3MBTL1MAPK1LMNA | |
| SCHEMBL8762963 | 0.81 | CTSB (0.51) | ALDH1A1TDP1L3MBTL1MAPK1SLC6A2 | |
| SCHEMBL939536 | 0.81 | ALDH1A1 (0.64) | ALDH1A1TDP1L3MBTL1MAPK1SLC6A2 | |
| SCHEMBL8392844 | 0.80 | LMNA (0.57) | ALDH1A1TDP1KMT2ALMNANPC1 | |
| SCHEMBL17527982 | 0.79 | ALDH1A1 (0.57) | ALDH1A1TDP1L3MBTL1MAPK1SLC6A2 | |
| SCHEMBL966323 | 0.79 | ALDH1A1 (0.62) | ALDH1A1TDP1L3MBTL1MAPK1SLC6A2 | |
| SCHEMBL2111562 | 0.79 | ALDH1A1 (0.61) | ALDH1A1TDP1L3MBTL1MAPK1SLC6A2 | |
| SCHEMBL602247 | 0.79 | ALDH1A1 (0.61) | ALDH1A1TDP1L3MBTL1MAPK1SLC6A2 | |
| SCHEMBL602246 | 0.79 | ALDH1A1 (0.61) | ALDH1A1TDP1L3MBTL1MAPK1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864043-A | CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST | KARL THOMAE GMBH (DE) | 1999-01-26 | — | — | US | disclosed |
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0392317-B1 | Benzimidazoles, drugs containing these compounds and process for their preparation | THOMAE GMBH DR K (DE) | 1996-01-03 | — | — | EP | disclosed |
| EP-0392317-A2 | Benzimidazoles, drugs containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1990-10-17 | — | — | EP | disclosed |