Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | JUN | P05412 | 6/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 6/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 6/20 | 0.52 |
| ▸ | RELA | Q04206 | 6/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | FOS | P01100 | 3/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8396932 | 0.90 | KDM4E (0.70) | KDM4EJUNNFKB1NFKB2RELA | |
| SCHEMBL8398281 | 0.87 | MAPT (0.49) | KDM4EJUNNFKB1NFKB2RELA | |
| SCHEMBL8394555 | 0.82 | KDM4E (0.58) | KDM4EJUNNFKB1NFKB2RELA | |
| SCHEMBL2354777 | 0.82 | KDM4E (0.58) | KDM4EJUNNFKB1NFKB2RELA | |
| SCHEMBL8394437 | 0.81 | KDM4E (0.56) | KDM4EJUNNFKB1NFKB2RELA | |
| SCHEMBL8725201 | 0.81 | KDM4E (0.47) | KDM4EJUNNFKB1NFKB2RELA | |
| SCHEMBL8398108 | 0.80 | RAB9A (0.64) | KDM4EJUNNFKB1NFKB2RELA | |
| SCHEMBL8396937 | 0.80 | KDM4E (0.41) | KDM4EJUNNFKB1NFKB2RELA | |
| SCHEMBL8398161 | 0.79 | RAB9A (0.49) | KDM4EJUNNFKB1NFKB2RELA | |
| SCHEMBL8398390 | 0.78 | JUN (0.60) | KDM4EJUNNFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5935966-A | COMPOUNDS THAT BLOCK THE ACTIVATION OF TRANSCRIPTION FACTORS THROUGH INHIBITION OF A FAMILY OF SPECIFIC KINASES, DECREASING PROINFLAMMATORY PROTEINS TO TREAT AUTOIMMUNE DISEASES AND AS GENERAL ANTIINFLAMMATORY AGENTS | SIGNAL PHARMACEUTICALS, INC. (US) | 1999-08-10 | — | — | US | disclosed |
| US-5852028-A | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions | SIGNAL PHARMACEUTICALS, INC. (US) | 1998-12-22 | — | — | US | disclosed |
| WO-1998038171-A1 | PYRIMIDINE CARBOXYLATES AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1998-09-03 | — | — | WO | disclosed |
| WO-1997009325-A1 | PYRIMIDINE CARBOXYLATES AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1997-03-13 | — | — | WO | disclosed |