Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 7/20 | 0.46 |
| ▸ | JUN | P05412 | 6/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 6/20 | 0.46 |
| ▸ | RELA | Q04206 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | FOS | P01100 | 3/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ATF1 | P18846 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8721324 | 0.93 | KDM4E (0.56) | KDM4ENFKB1JUNNFKB2RELA | |
| SCHEMBL8721355 | 0.91 | MAPT (0.41) | KDM4ENFKB1JUNNFKB2RELA | |
| SCHEMBL8721300 | 0.86 | RAB9A (0.52) | KDM4ENFKB1JUNNFKB2RELA | |
| SCHEMBL8726399 | 0.84 | RAB9A (0.42) | KDM4ENFKB1JUNNFKB2RELA | |
| SCHEMBL8889739 | 0.83 | MAPT (0.48) | KDM4ENFKB1JUNNFKB2RELA | |
| SCHEMBL8725171 | 0.83 | NFKB1 (0.52) | KDM4ENFKB1JUNNFKB2RELA | |
| SCHEMBL8724454 | 0.82 | HSP90AA1 (0.55) | KDM4ENFKB1JUNNFKB2RELA | |
| SCHEMBL8891103 | 0.81 | NFKB1 (0.52) | KDM4ENFKB1JUNNFKB2RELA | |
| SCHEMBL8721404 | 0.81 | NFKB1 (0.42) | KDM4ENFKB1JUNNFKB2RELA | |
| SCHEMBL8395161 | 0.81 | KDM4E (0.56) | KDM4ENFKB1JUNNFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998038171-A1 | PYRIMIDINE CARBOXYLATES AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1998-09-03 | — | — | WO | claimed |
| WO-1998038171-A1 | PYRIMIDINE CARBOXYLATES AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1998-09-03 | — | — | WO | disclosed |
| WO-1997009325-A1 | PYRIMIDINE CARBOXYLATES AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1997-03-13 | — | — | WO | disclosed |