Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | JUN | P05412 | 4/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.38 |
| ▸ | RELA | Q04206 | 4/20 | 0.38 |
| ▸ | CFTR | P13569 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6475927 | 0.89 | MAPT (0.60) | MAPTGAAALDH1A1KMT2AKDM4E | |
| SCHEMBL8395161 | 0.87 | KDM4E (0.56) | MAPTALDH1A1KDM4EJUNNFKB1 | |
| SCHEMBL8396937 | 0.84 | KDM4E (0.41) | MAPTGAAALDH1A1KDM4EJUN | |
| SCHEMBL8398360 | 0.80 | NFKB1 (0.56) | MAPTGAAJUNNFKB1NFKB2 | |
| SCHEMBL8721355 | 0.78 | MAPT (0.41) | MAPTGAAALDH1A1KMT2AKDM4E | |
| SCHEMBL8722111 | 0.77 | NFKB1 (0.60) | MAPTGAAALDH1A1KMT2AKDM4E | |
| SCHEMBL8396932 | 0.76 | KDM4E (0.70) | MAPTGAAKDM4EJUNNFKB1 | |
| SCHEMBL15038313 | 0.71 | KDM4E (0.72) | MAPTGAAALDH1A1KMT2AKDM4E | |
| SCHEMBL4592101 | 0.69 | MAPT (0.57) | MAPTGAAALDH1A1KMT2AKDM4E | |
| SCHEMBL8889739 | 0.69 | MAPT (0.48) | MAPTGAAALDH1A1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5935966-A | COMPOUNDS THAT BLOCK THE ACTIVATION OF TRANSCRIPTION FACTORS THROUGH INHIBITION OF A FAMILY OF SPECIFIC KINASES, DECREASING PROINFLAMMATORY PROTEINS TO TREAT AUTOIMMUNE DISEASES AND AS GENERAL ANTIINFLAMMATORY AGENTS | SIGNAL PHARMACEUTICALS, INC. (US) | 1999-08-10 | — | — | US | disclosed |
| WO-1998038171-A1 | PYRIMIDINE CARBOXYLATES AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1998-09-03 | — | — | WO | disclosed |
| WO-1997009325-A1 | PYRIMIDINE CARBOXYLATES AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1997-03-13 | — | — | WO | disclosed |