Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 4/20 | 0.60 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.45 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8392121 | 0.98 | MGLL (0.63) | MGLLENPP2NPC1ALDH1A1TP53 | |
| SCHEMBL8395178 | 0.87 | PARP1 (0.51) | MGLLENPP2ALDH1A1MAPTPOLB | |
| SCHEMBL8396200 | 0.82 | MAPK1 (0.58) | NPC1ALDH1A1MAPTRAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8395203 | 0.81 | MAPK1 (0.56) | NPC1ALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL8392021 | 0.79 | LMNA (0.50) | NPC1ALDH1A1MAPTTSHRRAB9A | |
| SCHEMBL8392960 | 0.79 | F10 (0.56) | NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL8397601 | 0.78 | LMNA (0.49) | NPC1ALDH1A1MAPTTSHRRAB9A | |
| SCHEMBL7376222 | 0.78 | DPP4 (0.49) | MGLLNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL8395561 | 0.78 | MAPT (0.68) | NPC1ALDH1A1MAPTRAB9ASMN1; SMN2 | |
| Oxalic Acid SCHEMBL8394089 | 0.77 | ALDH1A1 (0.60) | NPC1ALDH1A1TP53MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998399-A | Guanidine derivatives useful in therapy as inhibitors of nitric oxide synthetase | ASTRA AKTIEBOLAG (SE) | 1999-12-07 | — | — | US | disclosed |
| EP-0690851-B1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AB (SE) | 1999-05-19 | — | — | EP | disclosed |
| US-5885985-A | Guanidine derivatives useful in therapy | ASTRA AKTIEBOLAG (SE) | 1999-03-23 | — | — | US | disclosed |