Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | F2R | P25116 | 1/20 | 0.51 |
| ▸ | NR1I3 | Q14994 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8395203 | 0.99 | MAPK1 (0.56) | MAPK1MAPTLMNAHSD17B10ALDH1A1 | |
| SCHEMBL8392021 | 0.86 | LMNA (0.50) | MAPK1MAPTLMNAHSD17B10ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8397601 | 0.85 | LMNA (0.49) | MAPK1MAPTLMNAHSD17B10ALDH1A1 | |
| SCHEMBL8392121 | 0.84 | MGLL (0.63) | MAPTALDH1A1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL8392632 | 0.83 | POLB (0.57) | MAPTLMNAALDH1A1NPC1HTT | |
| Oxalic Acid SCHEMBL8395194 | 0.82 | MGLL (0.60) | MAPTALDH1A1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL7565149 | 0.82 | MAPK1 (0.81) | MAPK1MAPTLMNAHSD17B10ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8397107 | 0.82 | POLB (0.56) | MAPTLMNAALDH1A1NPC1HTT | |
| SCHEMBL8392821 | 0.81 | GAA (0.59) | MAPTHSD17B10ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL8392115 | 0.81 | POLB (0.55) | ALDH1A1NPC1HTTF2RSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690851-B1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AB (SE) | 1999-05-19 | — | — | EP | claimed |
| US-5885985-A | Guanidine derivatives useful in therapy | ASTRA AKTIEBOLAG (SE) | 1999-03-23 | — | — | US | claimed |
| EP-0690851-A1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | Astra Aktiebolag (SE) | 1996-01-10 | — | — | EP | claimed |
| WO-1994021621-A1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AKTIEBOLAG (SE) | 1994-09-29 | — | — | WO | claimed |