Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHB | P07195 | 9/20 | 0.52 |
| ▸ | LDHA | P00338 | 8/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | NOS3 | P29474 | 2/20 | 0.42 |
| ▸ | NOS1 | P29475 | 2/20 | 0.42 |
| ▸ | NOS2 | P35228 | 2/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9290115 | 0.85 | ESR1 (0.48) | ESR1ESR2KMT2AALDH1A1LMNA | |
| SCHEMBL839917 | 0.84 | LDHA (0.48) | LDHBLDHAEPHX2PPARGCNR2 | |
| SCHEMBL30410294 | 0.75 | LDHB (0.61) | LDHBLDHAPPARG | |
| SCHEMBL11900963 | 0.74 | KMT2A (0.50) | KMT2APPARGALDH1A1LMNACYP3A4 | |
| SCHEMBL20341737 | 0.73 | KMT2A (0.49) | KMT2APPARGALDH1A1LMNACYP3A4 | |
| SCHEMBL5364018 | 0.73 | LDHB (0.50) | LDHBLDHAESR1ESR2NOS3 | |
| SCHEMBL840330 | 0.73 | MAOB (0.45) | LDHBLDHANOS3NOS1NOS2 | |
| SCHEMBL18075387 | 0.72 | LDHB (0.49) | LDHBLDHAESR1ESR2NOS3 | |
| SCHEMBL268273 | 0.72 | KMT2A (0.48) | KMT2APPARGALDH1A1LMNACYP3A4 | |
| SCHEMBL268274 | 0.72 | KMT2A (0.48) | KMT2APPARGALDH1A1LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2331498-B1 | COLD MENTHOL RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2016-11-09 | — | — | EP | disclosed |
| EP-2331498-B1 | COLD MENTHOL RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2016-11-09 | — | — | EP | disclosed |
| EP-2331499-B1 | COLD MENTHOL RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2016-09-21 | — | — | EP | disclosed |
| EP-2331499-B1 | COLD MENTHOL RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2016-09-21 | — | — | EP | disclosed |
| US-9096521-B2 | Cold menthol receptor antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2015-08-04 | — | — | US | disclosed |
| US-9096521-B2 | Cold menthol receptor antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2015-08-04 | — | — | US | disclosed |
| US-20140128428-A1 | COLD MENTHOL RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA, NV (BE) | 2014-05-08 | — | — | US | disclosed |
| US-20140128428-A1 | COLD MENTHOL RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA, NV (BE) | 2014-05-08 | — | — | US | disclosed |
| US-8653099-B2 | Cold menthol receptor antagonists | JANSSEN PHARMACEUTICA (BE) | 2014-02-18 | — | — | US | disclosed |
| US-8653099-B2 | Cold menthol receptor antagonists | JANSSEN PHARMACEUTICA (BE) | 2014-02-18 | — | — | US | disclosed |
| WO-2010021878-A1 | COLD MENTHOL RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-02-25 | — | — | WO | disclosed |
| WO-2010021878-A1 | COLD MENTHOL RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-02-25 | — | — | WO | disclosed |
| WO-2010021882-A2 | COLD MENTHOL RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-02-25 | — | — | WO | disclosed |
| WO-2010021882-A2 | COLD MENTHOL RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-02-25 | — | — | WO | disclosed |
| US-20100048589-A1 | Cold Menthol Receptor Antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2010-02-25 | — | — | US | disclosed |
| US-20100048589-A1 | Cold Menthol Receptor Antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2010-02-25 | — | — | US | disclosed |
| US-20100048589-A1 | Cold Menthol Receptor Antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2010-02-25 | — | — | US | disclosed |
| US-20100048619-A1 | Cold Menthol Receptor Antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2010-02-25 | — | — | US | disclosed |
| US-20100048619-A1 | Cold Menthol Receptor Antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2010-02-25 | — | — | US | disclosed |
| US-20100048619-A1 | Cold Menthol Receptor Antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048589-A1 | Cold Menthol Receptor Antagonists | TRPV1, TRPM2, TRPM6 | LDHB 832/4885LDHA 999/4885ESR1 1424/4885 |
| US-20140128428-A1 | COLD MENTHOL RECEPTOR ANTAGONISTS | TRPV1, TRPM2, TRPM5 | LDHB 1181/4885LDHA 798/4885ESR1 1123/4885 |
| US-20100048619-A1 | Cold Menthol Receptor Antagonists | TRPV1, TRPM2, TRPM5 | LDHB 1189/4885LDHA 805/4885ESR1 1147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.