Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11292694 | 0.96 | CYP3A4 (0.39) | CYP3A4CYP2C19GAASLC6A2SLC6A4 | |
| SCHEMBL27451597 | 0.80 | CYP3A4 (0.43) | CYP3A4CYP2C19GAASLC6A2SLC6A4 | |
| SCHEMBL1645022 | 0.77 | HPGD (0.43) | CYP3A4CYP2C19GAASLC6A2SLC6A4 | |
| SCHEMBL6281222 | 0.77 | CYP3A4 (0.40) | CYP3A4CYP2C19GAASLC6A2SLC6A4 | |
| SCHEMBL7343137 | 0.77 | CYP3A4 (0.40) | CYP3A4CYP2C19GAASLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL4971841 | 0.75 | CYP3A4 (0.39) | CYP3A4CYP2C19GAASLC6A2SLC6A4 | |
| SCHEMBL11554283 | 0.75 | HPGD (0.42) | CYP3A4CYP2C19GAASLC6A2SLC6A4 | |
| SCHEMBL115279 | 0.71 | HSD17B10 (0.38) | CYP3A4CYP2C19SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL14720080 | 0.69 | NAPRT (0.39) | CYP3A4CYP2C19GAASLC6A2SLC6A4 | |
| SCHEMBL2840806 | 0.68 | CYP2C19 (0.40) | CYP3A4CYP2C19GAASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0611372-B1 | PHOTOSENSITIZERS | JOHNSON MATTHEY PLC (GB) | 1999-05-26 | — | — | EP | disclosed |