SCHEMBL1237373

SCHEMBL1237373

CCCCCCCCCCCC(=O)Nc1ccc(C)cc1NC(=O)CCCCCCCCCCC

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 3/20 0.72
L3MBTL1 Q9Y468 2/20 0.72
TDP1 Q9NUW8 1/20 0.72
HDAC3 O15379 2/20 0.60
HDAC4 P56524 2/20 0.60
HDAC1 Q13547 2/20 0.60
HDAC7 Q8WUI4 2/20 0.60
HDAC2 Q92769 2/20 0.60
HDAC10 Q969S8 2/20 0.60
HDAC11 Q96DB2 2/20 0.60
HDAC8 Q9BY41 2/20 0.60
HDAC6 Q9UBN7 2/20 0.60
HDAC9 Q9UKV0 2/20 0.60
HDAC5 Q9UQL6 2/20 0.60
EP300 Q09472 1/20 0.56
CYP1A2 P05177 1/20 0.55
CYP2C9 P11712 1/20 0.55
CYP2C19 P33261 1/20 0.55
CETP P11597 1/20 0.55
SOAT1 P35610 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14984048 1.00 GAA (0.72) GAAL3MBTL1TDP1HDAC3HDAC4
SCHEMBL13412608 0.88 GAA (0.74) GAAL3MBTL1TDP1HDAC3HDAC4
SCHEMBL13412596 0.88 GAA (0.74) GAAL3MBTL1TDP1HDAC3HDAC4
SCHEMBL13412595 0.88 GAA (0.74) GAAL3MBTL1TDP1HDAC3HDAC4
SCHEMBL13412593 0.88 GAA (0.74) GAAL3MBTL1TDP1HDAC3HDAC4
SCHEMBL13412604 0.88 GAA (0.74) GAAL3MBTL1TDP1HDAC3HDAC4
SCHEMBL13412598 0.88 GAA (0.74) GAAL3MBTL1TDP1HDAC3HDAC4
SCHEMBL13412597 0.88 GAA (0.74) GAAL3MBTL1TDP1HDAC3HDAC4
SCHEMBL13412605 0.88 GAA (0.74) GAAL3MBTL1TDP1HDAC3HDAC4
SCHEMBL13412607 0.88 GAA (0.74) GAAL3MBTL1TDP1HDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7820146-B2 Care and/or make-up cosmetic composition structured with silicone polymers and organogelling agents, in rigid form L'OREAL S.A. (FR) 2010-10-26 US claimed
US-20050245673-A1 Care and/or make-up cosmetic composition structured with silicone polymers and organogelling agents, in rigid form L'OREAL S.A. (FR) 2005-11-03 US claimed
US-20040223987-A1 Composition structured with a polymer containing a heteroatom and organogelator L'OREAL S.A. (FR) 2004-11-11 US claimed
US-6726915-B2 DIAMIDE COMPOUNDS RETAINING GOOD COSMETIC PROPERTIES, IN PARTICULAR A CERTAIN LEVEL OF L'OREAL (FR) 2004-04-27 US claimed
US-20030129211-A9 Cosmetic or pharmaceutical composition in solid form comprising bis-acyl-amides L'OREAL S.A. (FR) 2003-07-10 US claimed
US-20020150602-A1 Cosmetic or pharmaceutical composition in solid form comprising bis-acyl-amides LIVOREIL AUDE (FR) 2002-10-17 US claimed
EP-1676556-B1 Cosmetic composition containing a polyorganosiloxane polymer OREAL (FR) 2012-01-11 EP disclosed
US-20110189117-A1 COSMETIC COMPOSITION CONTAINING A POLYORGANISILOXANE POLYMER L'OREAL (FR) 2011-08-04 US disclosed
US-7879316-B2 Mixture of polyamide-siloxane copolymer in volatile oil; cosmetics L'OREAL (FR) 2011-02-01 US disclosed
US-7820146-B2 Care and/or make-up cosmetic composition structured with silicone polymers and organogelling agents, in rigid form L'OREAL S.A. (FR) 2010-10-26 US disclosed
US-7803356-B2 Compositions containing at least one silicone resin and a volatile non-cyclic silicone oil L'OREAL (FR) 2010-09-28 US disclosed
US-7758848-B2 Cosmetic composition containing a polyorganosiloxane polymer L'OREAL (FR) 2010-07-20 US disclosed
US-20080057011-A1 Composition structured with a polymer containing a heteroatom and an Organogelator L'OREAL S.A., 2008-03-06 US disclosed
US-20040170586-A1 Cosmetic composition containing a polyorganosiloxane polymer L'OREAL (FR) 2004-09-02 US disclosed
US-6726915-B2 DIAMIDE COMPOUNDS RETAINING GOOD COSMETIC PROPERTIES, IN PARTICULAR A CERTAIN LEVEL OF L'OREAL (FR) 2004-04-27 US disclosed
WO-2003105788-A2 CARE AND/OR MAKE-UP COSMETIC COMPOSITION STRUCTURED WITH SILICONE POLYMERS AND ORGANOGELLING AGENTS, IN RIGID FORM L'OREAL (FR) 2003-12-24 WO disclosed
US-20030129211-A9 Cosmetic or pharmaceutical composition in solid form comprising bis-acyl-amides L'OREAL S.A. (FR) 2003-07-10 US disclosed
EP-1294342-A2 COMPOSITION STRUCTURED WITH A POLYMER CONTAINING AHETEROATOM AND AN ORGANOGELATOR L'OREAL (FR) 2003-03-26 EP disclosed
US-20020150602-A1 Cosmetic or pharmaceutical composition in solid form comprising bis-acyl-amides LIVOREIL AUDE (FR) 2002-10-17 US disclosed
WO-2002055030-A2 COMPOSITION STRUCTURED WITH A POLYMER CONTAINING A HETEROATOM AND ORGANOGELATOR OREAL (FR) 2002-07-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080057011-A1 Composition structured with a polymer containing a heteroatom and an Organogelator CUTA, FABP4, PARG GAA 2234/4885L3MBTL1 1777/4885TDP1 861/4885
US-20040223987-A1 Composition structured with a polymer containing a heteroatom and organogelator CUTA, PARG, FABP4 GAA 2789/4885L3MBTL1 1721/4885TDP1 631/4885
US-20030129211-A9 Cosmetic or pharmaceutical composition in solid form comprising bis-acyl-amides FAAH, HRH1, HRH4 GAA 1677/4885L3MBTL1 4572/4885TDP1 4423/4885
US-20040170586-A1 Cosmetic composition containing a polyorganosiloxane polymer CUTA, XPA, PRDX1 GAA 702/4885L3MBTL1 3687/4885TDP1 426/4885
US-20020150602-A1 Cosmetic or pharmaceutical composition in solid form comprising bis-acyl-amides FAAH, HRH1, HRH4 GAA 1677/4885L3MBTL1 4572/4885TDP1 4423/4885
US-20110189117-A1 COSMETIC COMPOSITION CONTAINING A POLYORGANISILOXANE POLYMER CUTA, PRDX1, PRXL2A GAA 1291/4885L3MBTL1 2518/4885TDP1 649/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.