Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | LAP3 | P28838 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19924444 | 0.90 | PKM (0.40) | PKMCA2CA1CA9AKR1B10 | |
| SCHEMBL18787609 | 0.83 | CA2 (0.43) | CA2CA1CA9HCAR2TSHR | |
| SCHEMBL6828915 | 0.83 | CA2 (0.43) | CA2CA1CA9HCAR2TSHR | |
| SCHEMBL27254359 | 0.82 | PKM (0.54) | PKMCA2CA1CA9HCAR2 | |
| SCHEMBL11541899 | 0.82 | NPC1 (0.44) | CA2CA1CA9KDM4ELMNA | |
| SCHEMBL8619121 | 0.81 | TSHR (0.57) | PKMCA2TSHRLAP3KDM4E | |
| SCHEMBL27921183 | 0.80 | TSHR (0.52) | CA2CA1CA9TSHRLAP3 | |
| SCHEMBL17573316 | 0.79 | TSHR (0.50) | CA2CA1CA9TSHRTDP1 | |
| SCHEMBL2817045 | 0.78 | CA1 (0.48) | PKMCA2CA1CA9HCAR2 | |
| SCHEMBL10875408 | 0.77 | ALOX5 (0.48) | KDM4ELMNATDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915704-A1 | USE OF PHOSPHINYLOXYALKYL AND PHOSPHONAMIDOALKYL DERIVATIVES OF CYCLOPENTANE(ENE) AS THERAPEUTIC AGENTS | Vision Pharmaceuticals L.P. (US) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997037666-A1 | USE OF PHOSPHINYLOXYALKYL AND PHOSPHONAMIDOALKYL DERIVATIVES OF CYCLOPENTANE(ENE) AS THERAPEUTIC AGENTS | ALLERGAN SALES, INC. (US) | 1997-10-16 | — | — | WO | disclosed |
| US-5658897-A | MUSCLE RELAXANTS AND OCULAR HYPOTENSIVE AGENTS | ALLERGAN (US) | 1997-08-19 | — | — | US | disclosed |