SCHEMBL8397967

SCHEMBL8397967

Cc1sccc1NCc1nc2c(F)c(F)ccc2s1

nearest known ligand 0.34

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AKR1B1 P15121 1/20 0.34
TRPM5 Q9NZQ8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8395826 0.81 AKR1B1 (0.41) AKR1B1
SCHEMBL8399039 0.81 ADRA2C (0.40) AKR1B1
SCHEMBL8400276 0.80 MEN1 (0.42) AKR1B1TRPM5
SCHEMBL8397947 0.80 PDE4A (0.31)
SCHEMBL8398066 0.79 KDM4E (0.41) AKR1B1TRPM5
SCHEMBL8399104 0.78 MAPT (0.39) AKR1B1TRPM5
SCHEMBL8397959 0.77 ADRA1D (0.40) AKR1B1TRPM5
SCHEMBL8395348 0.76 AKR1B1 (0.39) AKR1B1TRPM5
SCHEMBL8398186 0.76 AKR1B1 (0.39) AKR1B1TRPM5
SCHEMBL8395550 0.76 L3MBTL1 (0.44) AKR1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0647636-B1 BENZOTHIAZOLE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF SENJU PHARMA CO (JP) 1999-06-09 EP disclosed
US-5532257-A ENZYME INHIBITOR SENJU PHARMACEUTICAL CO., LTD (JP) 1996-07-02 US disclosed
EP-0647636-A1 BENZOTHIAZOLE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF Senju Pharmaceutical Co., Ltd. (JP) 1995-04-12 EP disclosed