SCHEMBL8399356

SCHEMBL8399356

COC(=O)c1ccccc1OCC(=O)COc1ccccc1C(=O)OC

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.59
TSHR P16473 2/20 0.59
SLC6A3 Q01959 2/20 0.56
HSP90AA1 P07900 2/20 0.54
MAPT P10636 2/20 0.54
HTT P42858 1/20 0.54
NPSR1 Q6W5P4 1/20 0.54
CYP2C9 P11712 3/20 0.52
CYP2C19 P33261 3/20 0.52
KMT2A Q03164 2/20 0.52
CYP1A2 P05177 2/20 0.52
CYP3A4 P08684 1/20 0.52
LMNA P02545 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.51
MEN1 O00255 1/20 0.51
GAA P10253 1/20 0.51
HPGD P15428 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
CFTR P13569 1/20 0.50
HSD17B10 Q99714 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1280991 0.88 POLB (0.64) ALDH1A1TSHRSLC6A3HSP90AA1MAPT
SCHEMBL3783343 0.88 ALDH1A1 (0.58) ALDH1A1TSHRSLC6A3HSP90AA1MAPT
SCHEMBL27524567 0.86 ALDH1A1 (0.57) ALDH1A1TSHRSLC6A3HSP90AA1MAPT
SCHEMBL8379922 0.85 ALDH1A1 (0.56) ALDH1A1TSHRSLC6A3HSP90AA1MAPT
SCHEMBL5487845 0.85 ALDH1A1 (0.63) ALDH1A1TSHRSLC6A3HSP90AA1MAPT
SCHEMBL31425872 0.84 ALDH1A1 (0.52) ALDH1A1TSHRSLC6A3HSP90AA1MAPT
SCHEMBL20235270 0.84 ALDH1A1 (0.52) ALDH1A1TSHRSLC6A3HSP90AA1MAPT
SCHEMBL1989129 0.84 HCRTR1 (0.65) ALDH1A1TSHRSLC6A3HSP90AA1MAPT
SCHEMBL30553984 0.84 HCRTR1 (0.65) ALDH1A1TSHRSLC6A3HSP90AA1MAPT
SCHEMBL28136228 0.84 SLC6A3 (0.57) ALDH1A1TSHRSLC6A3HSP90AA1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0667854-B1 PEPTIDYL ACTIVATED KETONE INHIBITORS CONTAINING NATURAL AND UNNATURAL PEPTIDE SEQUENCES PROTOTEK INC (US) 1999-06-02 EP disclosed
EP-0667854-A1 PEPTIDYL ACTIVATED KETONE INHIBITORS CONTAINING NATURAL AND UNNATURAL PEPTIDE SEQUENCES PROTOTEK, INC., (US) 1995-08-23 EP disclosed
EP-0667854-A4 PEPTIDYL ACTIVATED KETONE INHIBITORS CONTAINING NATURAL AND UNNATURAL PEPTIDE SEQUENCES. PROTOTEK INC (US) 1995-07-04 EP disclosed
US-5374623-A Cysteine protease inhibitors effective for in vivo use PROTOTEK, INC. (US) 1994-12-20 US disclosed
WO-1994004172-A1 PEPTIDYL ACTIVATED KETONE INHIBITORS CONTAINING NATURAL AND UNNATURAL PEPTIDE SEQUENCES PROTOTEK, INC. (US) 1994-03-03 WO disclosed