Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 6/20 | 0.42 |
| ▸ | CCKAR | P32238 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8398505 | 0.89 | CCKBR (0.41) | CCKBR | |
| SCHEMBL8399465 | 0.88 | CCKBR (0.43) | CCKBRCCKAR | |
| SCHEMBL8398474 | 0.86 | CCKBR (0.34) | CCKBRLMNANPSR1 | |
| SCHEMBL8398988 | 0.86 | CCKBR (0.41) | CCKBR | |
| SCHEMBL8403199 | 0.84 | CCKBR (0.42) | CCKBRLMNANPSR1 | |
| SCHEMBL8401333 | 0.81 | CCKBR (0.65) | CCKBR | |
| SCHEMBL8399005 | 0.77 | CCKBR (0.37) | CCKBR | |
| SCHEMBL8401329 | 0.75 | CCKBR (0.40) | CCKBRMEN1KMT2A | |
| SCHEMBL8402444 | 0.74 | CCKBR (0.49) | CCKBRMEN1KMT2A | |
| SCHEMBL8403211 | 0.74 | CCKBR (0.49) | CCKBRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711283-B1 | TETRAHYDRO-1H-BENZAZEPINONES AND HEXAHYDROAZEPINONES AS SELECTIVE CHOLECYSTOKININ-B RECEPTOR ANTAGONISTS | PFIZER (US) | 1999-06-16 | — | — | EP | disclosed |
| US-5618811-A | Tetrahydro-1H-benzazepinones and hexahydroazepinones as selective cholecystokinin-B receptor antagonists | PFIZER INC. (US) | 1997-04-08 | — | — | US | disclosed |