Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 17/20 | 1.00 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.96 |
| ▸ | GRIK3 | Q13003 | 4/20 | 0.96 |
| ▸ | GRIK5 | Q16478 | 4/20 | 0.96 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.96 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.96 |
| ▸ | GRIK2 | Q13002 | 7/20 | 0.54 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8403414 | 0.98 | GRIK1 (1.00) | GRIK1GRIA4GRIK3GRIK5GRIA2 | |
| SCHEMBL8403565 | 0.94 | GRIK1 (1.00) | GRIK1GRIA4GRIK3GRIK5GRIA2 | |
| SCHEMBL9813656 | 0.71 | GRIK1 (0.55) | GRIK1GRIA4GRIK3GRIK5GRIA2 | |
| SCHEMBL6682947 | 0.70 | GRIK1 (0.53) | GRIK1GRIA4GRIK3GRIK5GRIA2 | |
| SCHEMBL28661006 | 0.70 | GRIK1 (0.53) | GRIK1GRIA4GRIK3GRIK5GRIA2 | |
| SCHEMBL6341738 | 0.70 | GRIK1 (0.53) | GRIK1GRIA4GRIK3GRIK5GRIA2 | |
| Hydrochloric Acid SCHEMBL8404132 | 0.69 | GRIK1 (0.97) | GRIK1GRIA4GRIK3GRIK5GRIA2 | |
| SCHEMBL8877421 | 0.69 | GRIK1 (0.53) | GRIK1GRIA4GRIK3GRIK5GRIA2 | |
| SCHEMBL17165762 | 0.67 | GRIK1 (0.52) | GRIK1GRIA4GRIK3GRIK5GRIA2 | |
| Aspartic Acid SCHEMBL886966 | 0.64 | GRIK1 (0.58) | GRIK1GRIA4GRIK3GRIK5GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0867430-A2 | Glutamic acid derivatives and pharmaceutical compositions for the treatment of central nervous system disorders | LILLY S.A. (ES) | 1998-09-30 | — | — | EP | claimed |
| US-5990165-A | AN UNSATURATED ALPHA-AMINO CARBOXYLIC ACID TO MODIFY NEUROTRANSMISSION BY INTERACTION WITH IONOTROPIC AND MEETABOTROPIC RECEPTORS; CENTRAL NERVOUS SYSTEM DISORDERS; | LILLY, S.A. (ES) | 1999-11-23 | — | — | US | disclosed |
| EP-0867430-A2 | Glutamic acid derivatives and pharmaceutical compositions for the treatment of central nervous system disorders | LILLY S.A. (ES) | 1998-09-30 | — | — | EP | disclosed |