SCHEMBL8400307

SCHEMBL8400307

CC(C)(NC(=O)c1cc(Cl)c(Cl)c(Cl)c1)C(=O)C(Cl)Br

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 1/20 0.35
KDM4E B2RXH2 2/20 0.33
ALDH1A1 P00352 2/20 0.33
GAA P10253 1/20 0.33
POLB P06746 2/20 0.33
APEX1 P27695 1/20 0.33
LMNA P02545 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32
MAPT P10636 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32
HTT P42858 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
GPR55 Q9Y2T6 1/20 0.32
GRN P28799 3/20 0.32
SORT1 Q99523 3/20 0.32
CHRNA1 P02708 1/20 0.32
CHRNG P07510 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8403493 0.90 CNR2 (0.34) CNR2KDM4EALDH1A1GAAPOLB
SCHEMBL8403929 0.86 GRN (0.44) GAACYP2D6GRNSORT1MEN1
SCHEMBL9010774 0.82 KDM4E (0.43) CNR2KDM4EALDH1A1POLBCYP1A2
SCHEMBL9010823 0.81 CYP3A4 (0.43) CNR2ALDH1A1POLBCYP3A4MAPT
SCHEMBL8400113 0.78 SLC6A2 (0.48) KDM4EALDH1A1POLBCYP2C19CHRNA1
SCHEMBL9821338 0.76 PLAU (0.39) CNR2POLBCYP1A2CYP2C19NPC1
SCHEMBL8403419 0.75 ALDH1A1 (0.54) CNR2KDM4EALDH1A1GAALMNA
SCHEMBL8400032 0.75 GRN (0.46) GAACYP2D6GRNSORT1MEN1
SCHEMBL8400028 0.75 HPGD (0.49) KDM4EPOLBCYP1A2MAPTCYP2C9
SCHEMBL8403842 0.72 TAS1R3 (0.46) GRNSORT1SLC6A3RAPGEF3RAPGEF4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5859063-A Use of certain N-acetonylbenzamides as fungicides ROHM AND HAAS COMPANY (US) 1999-01-12 US disclosed
US-5629346-A LOW TOXICITY ROHM AND HAAS COMPANY (US) 1997-05-13 US disclosed
US-4822902-A LOW PHYTOTOXICITY ROHM AND HAAS COMPANY (US) 1989-04-18 US disclosed
EP-0173453-B1 SUBSTITUTED N-ACETONYLBENZAMIDES AND THEIR USE AS FUNGICIDES ROHM AND HAAS COMPANY (US) 1988-07-13 EP disclosed
EP-0173453-A1 Substituted N-acetonylbenzamides and their use as fungicides ROHM AND HAAS COMPANY (US) 1986-03-05 EP disclosed