SCHEMBL8400512

SCHEMBL8400512

Cc1ccc(C(=O)P(=O)(c2ccccc2)c2ccccc2)c(C)c1

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
NFE2L2 Q16236 1/20 0.49
KMT2A Q03164 3/20 0.48
RAB9A P51151 4/20 0.47
SMN1; SMN2 Q16637 3/20 0.47
NPC1 O15118 3/20 0.47
HSD11B1 P28845 1/20 0.47
AVPR2 P30518 1/20 0.46
GPR27 Q9NS67 1/20 0.46
HTT P42858 2/20 0.45
LMNA P02545 2/20 0.44
HDAC7 Q8WUI4 1/20 0.43
MEN1 O00255 2/20 0.42
NPSR1 Q6W5P4 1/20 0.41
TSHR P16473 1/20 0.41
HSD17B10 Q99714 1/20 0.41
POLB P06746 1/20 0.41
ATM Q13315 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6548792 0.87 NFE2L2 (0.53) NFE2L2KMT2ARAB9ASMN1; SMN2NPC1
SCHEMBL10527135 0.85 NFE2L2 (0.48) NFE2L2KMT2ARAB9ASMN1; SMN2NPC1
SCHEMBL1186385 0.83 KMT2A (0.41) KMT2ARAB9ANPC1HTTLMNA
SCHEMBL29634650 0.83 KMT2A (0.41) KMT2ARAB9ANPC1HTTLMNA
SCHEMBL57823 0.82 HPGD (0.50) KMT2ARAB9ASMN1; SMN2NPC1HTT
SCHEMBL58567 0.81 NFE2L2 (0.44) NFE2L2KMT2ARAB9ASMN1; SMN2NPC1
SCHEMBL14998127 0.80 NFE2L2 (0.47) NFE2L2KMT2ARAB9ASMN1; SMN2NPC1
SCHEMBL27651 0.79 LMNA (0.43) KMT2ARAB9ASMN1; SMN2NPC1HTT
SCHEMBL27967065 0.79 LMNA (0.43) KMT2ARAB9ASMN1; SMN2NPC1HTT
SCHEMBL83199 0.79 LMNA (0.56) KMT2ARAB9ASMN1; SMN2NPC1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5916495-A COMPRISING POLYMETHYL METHACRYLATE AND A CLADDING LAYER; VARYING REFRACTIVE INDEX SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1999-06-29 US disclosed
US-5891570-A Plastic optical fiber preform having a jacket layer SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1999-04-06 US disclosed
US-5851666-A Plastic optical fiber preform, and process and apparatus for producing the same SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1998-12-22 US disclosed
US-5639512-A REFRACTIVE INDEX GRADIENTS SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1997-06-17 US disclosed
US-5614253-A DEPOSITING POLYMER LAYER WITH REFRACTIVE INDEX MODIFIER SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1997-03-25 US disclosed
EP-0664463-A1 PLASTIC OPTICAL FIBER BASE MATERIAL, PRODUCTION METHOD THEREFOR, AND APPARATUS THEREFOR SUMITOMO ELECTRIC INDUSTRIES, LIMITED (JP) 1995-07-26 EP disclosed
EP-0662620-A1 PRODUCTION METHOD AND APPARATUS FOR PLASTIC OPTICAL FIBER BASE MATERIAL SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1995-07-12 EP disclosed