SCHEMBL8401162

SCHEMBL8401162

Cc1ccc(C(=O)Sc2ccccc2)c(C)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NFE2L2 Q16236 1/20 0.50
KMT2A Q03164 3/20 0.49
HSD11B1 P28845 1/20 0.48
NPC1 O15118 2/20 0.44
RAB9A P51151 2/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
MAOA P21397 1/20 0.43
MAOB P27338 1/20 0.43
MAPK1 P28482 1/20 0.43
MEN1 O00255 1/20 0.43
TTR P02766 1/20 0.43
MAPT P10636 3/20 0.42
PKM P14618 1/20 0.42
ALDH1A1 P00352 2/20 0.42
POLB P06746 1/20 0.41
HSP90AA1 P07900 1/20 0.41
AVPR2 P30518 1/20 0.41
GPR27 Q9NS67 1/20 0.41
HDAC7 Q8WUI4 1/20 0.41
TDP1 Q9NUW8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL776388 0.82 L3MBTL1 (0.51) KMT2ANPC1RAB9ASMN1; SMN2MAOA
SCHEMBL8398564 0.80 NR1I2 (0.48) KMT2ANPC1RAB9AMAPK1MEN1
SCHEMBL775576 0.78 NPC1 (0.64) KMT2ANPC1RAB9ASMN1; SMN2MAOA
SCHEMBL775141 0.77 KMT2A (0.49) NFE2L2KMT2AHSD11B1NPC1RAB9A
SCHEMBL777000 0.74 TTR (0.57) KMT2ANPC1RAB9ASMN1; SMN2MEN1
SCHEMBL28674201 0.74 KMT2A (0.43) NFE2L2KMT2AHSD11B1NPC1RAB9A
SCHEMBL8363453 0.74 MAOA (0.43) KMT2AMAOAMAOBTTRMAPT
SCHEMBL30679777 0.73 CSNK2A1 (0.59) NFE2L2KMT2AHSD11B1SMN1; SMN2MEN1
SCHEMBL107259 0.73 CSNK2A1 (0.59) NFE2L2KMT2AHSD11B1SMN1; SMN2MEN1
SCHEMBL29380078 0.73 AKR1C3 (0.59) NFE2L2KMT2AHSD11B1NPC1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5916495-A COMPRISING POLYMETHYL METHACRYLATE AND A CLADDING LAYER; VARYING REFRACTIVE INDEX SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1999-06-29 US disclosed
US-5891570-A Plastic optical fiber preform having a jacket layer SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1999-04-06 US disclosed
US-5851666-A Plastic optical fiber preform, and process and apparatus for producing the same SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1998-12-22 US disclosed
US-5639512-A REFRACTIVE INDEX GRADIENTS SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1997-06-17 US disclosed
US-5614253-A DEPOSITING POLYMER LAYER WITH REFRACTIVE INDEX MODIFIER SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1997-03-25 US disclosed
EP-0664463-A1 PLASTIC OPTICAL FIBER BASE MATERIAL, PRODUCTION METHOD THEREFOR, AND APPARATUS THEREFOR SUMITOMO ELECTRIC INDUSTRIES, LIMITED (JP) 1995-07-26 EP disclosed
EP-0662620-A1 PRODUCTION METHOD AND APPARATUS FOR PLASTIC OPTICAL FIBER BASE MATERIAL SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1995-07-12 EP disclosed