SCHEMBL8398564

SCHEMBL8398564

Cc1cc(C)c(C(=O)Sc2ccccc2)c(C)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR1I2 O75469 2/20 0.48
TTR P02766 1/20 0.46
MAPT P10636 4/20 0.42
MAPK1 P28482 1/20 0.40
KMT2A Q03164 3/20 0.39
LMNA P02545 2/20 0.39
ALDH1A1 P00352 2/20 0.39
MEN1 O00255 2/20 0.39
NPC1 O15118 2/20 0.39
HTT P42858 1/20 0.39
NPSR1 Q6W5P4 1/20 0.38
CRHR1 P34998 1/20 0.38
TERT O14746 1/20 0.38
NR3C1 P04150 1/20 0.38
PGR P06401 1/20 0.38
NR3C2 P08235 1/20 0.38
POLB P06746 1/20 0.38
HSP90AA1 P07900 1/20 0.38
RAB9A P51151 1/20 0.38
MMP1 P03956 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28983775 0.86 MAPT (0.51) NR1I2MAPTKMT2ALMNAALDH1A1
SCHEMBL8401162 0.80 NFE2L2 (0.50) TTRMAPTMAPK1KMT2ALMNA
SCHEMBL7097296 0.75 HPGD (0.56) KMT2ALMNAALDH1A1MEN1NPSR1
SCHEMBL776388 0.74 L3MBTL1 (0.51) TTRMAPTKMT2ALMNAALDH1A1
SCHEMBL775576 0.74 NPC1 (0.64) TTRMAPTKMT2ALMNAALDH1A1
SCHEMBL777000 0.74 TTR (0.57) TTRMAPTKMT2ALMNAALDH1A1
SCHEMBL15823936 0.74 LMNA (0.37) MAPK1KMT2ALMNAMEN1NPC1
SCHEMBL50648 0.74 KMT2A (0.56) MAPTKMT2ALMNAALDH1A1MEN1
SCHEMBL29127418 0.73 LMNA (0.40) MAPTKMT2ALMNAMEN1NPC1
Benzophenone SCHEMBL3324674 0.72 ALDH1A1 (0.58) KMT2ALMNAALDH1A1MEN1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5916495-A COMPRISING POLYMETHYL METHACRYLATE AND A CLADDING LAYER; VARYING REFRACTIVE INDEX SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1999-06-29 US disclosed
US-5891570-A Plastic optical fiber preform having a jacket layer SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1999-04-06 US disclosed
US-5851666-A Plastic optical fiber preform, and process and apparatus for producing the same SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1998-12-22 US disclosed
US-5639512-A REFRACTIVE INDEX GRADIENTS SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1997-06-17 US disclosed
US-5614253-A DEPOSITING POLYMER LAYER WITH REFRACTIVE INDEX MODIFIER SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1997-03-25 US disclosed
EP-0664463-A1 PLASTIC OPTICAL FIBER BASE MATERIAL, PRODUCTION METHOD THEREFOR, AND APPARATUS THEREFOR SUMITOMO ELECTRIC INDUSTRIES, LIMITED (JP) 1995-07-26 EP disclosed
EP-0662620-A1 PRODUCTION METHOD AND APPARATUS FOR PLASTIC OPTICAL FIBER BASE MATERIAL SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1995-07-12 EP disclosed