Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8924517 | 0.86 | HTR1D (0.81) | HTR1DHTR1B | |
| SCHEMBL8402669 | 0.82 | HTR1D (0.59) | HTR1DHTR1B | |
| SCHEMBL2405832 | 0.77 | NOTUM (0.61) | — | |
| SCHEMBL7846607 | 0.74 | FAAH (0.58) | — | |
| SCHEMBL8058959 | 0.73 | HTR1D (0.67) | HTR1DHTR1B | |
| SCHEMBL31077788 | 0.73 | TRPV1 (0.70) | — | |
| SCHEMBL798165 | 0.73 | TRPV1 (0.70) | — | |
| SCHEMBL8613795 | 0.73 | TRPV1 (0.55) | — | |
| SCHEMBL8926188 | 0.72 | HTR1D (0.73) | HTR1DHTR1B | |
| SCHEMBL7318352 | 0.72 | MTNR1A (0.70) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998415-A | Bicyclic heteroaryl-alkylene-(homo)piperazinones and thione analogues thereof, their preparation, and their use of as selective agonists of 5-HT1 -like receptors | MERCK SHARP & DOHME LTD. (GB) | 1999-12-07 | — | — | US | disclosed |
| WO-1997016446-A1 | BICYCLIC HETEROARYL-ALKYLENE-(HOMO)PIPERAZINONES AND THIONE ANALOGUES THEREOF, THEIR PREPARATION AND THEIR USE AS SELECTIVE AGONISTS OF 5-HT1-LIKE RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 1997-05-09 | — | — | WO | disclosed |