Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 10/20 | 0.54 |
| ▸ | HSP90AB1 | P08238 | 9/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | XBP1 | P17861 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | COMT | P21964 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12047072 | 0.81 | SLC40A1 (0.46) | HSP90AA1HSP90AB1KDM4ETDP1NPC1 | |
| SCHEMBL12047079 | 0.79 | PSMD14 (0.57) | HSP90AA1KDM4ETDP1NPC1RAB9A | |
| SCHEMBL8581634 | 0.76 | KDM4E (0.54) | HSP90AA1KDM4ETDP1NPC1RAB9A | |
| SCHEMBL11808148 | 0.76 | COMT (0.61) | HSP90AA1HSP90AB1KDM4ETDP1NPC1 | |
| SCHEMBL8401986 | 0.76 | CYP1A2 (0.61) | HSP90AA1HSP90AB1KDM4ETDP1RAB9A | |
| SCHEMBL7897309 | 0.74 | KDM4E (0.56) | HSP90AA1KDM4ETDP1NPC1RAB9A | |
| SCHEMBL3688928 | 0.74 | L3MBTL1 (0.56) | HSP90AA1HSP90AB1KDM4ETDP1NPC1 | |
| SCHEMBL8401985 | 0.73 | CYP3A4 (0.51) | HSP90AA1KDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL8404766 | 0.73 | TOP1 (0.44) | HSP90AA1HSP90AB1KDM4ETDP1NPC1 | |
| SCHEMBL14242732 | 0.73 | HSP90AA1 (0.54) | HSP90AA1HSP90AB1KDM4ETDP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070293530-A1 | SULFAMIDE AND SULFAMATE DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | METHYLGENE INC. (CA) | 2007-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293530-A1 | SULFAMIDE AND SULFAMATE DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC11, HAT1 | HSP90AA1 2256/4885HSP90AB1 1565/4885KDM4E 215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.