Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ANO1 | Q5XXA6 | 9/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ANO2 | Q9NQ90 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25128559 | 0.79 | ANO1 (0.35) | ADRA2AANO1SMN1; SMN2TP53MAPT | |
| SCHEMBL8405478 | 0.78 | PTGES (0.39) | ANO1SMN1; SMN2TP53MAPTMTNR1A | |
| SCHEMBL25128558 | 0.78 | ANO1 (0.34) | ADRA2AANO1SMN1; SMN2TP53MAPT | |
| SCHEMBL13216300 | 0.75 | ALDH1A1 (0.41) | ADRA2AMAPTMTNR1AMTNR1BKDM4E | |
| SCHEMBL25128560 | 0.73 | F2 (0.35) | ADRA2AANO1SMN1; SMN2MTNR1AMTNR1B | |
| SCHEMBL25692525 | 0.72 | L3MBTL1 (0.40) | SMN1; SMN2MAPTMAOAKDM4ELMNA | |
| SCHEMBL8545657 | 0.71 | PARP1 (0.49) | ADRA2ATP53MAPTL3MBTL1 | |
| SCHEMBL25128557 | 0.70 | ANO1 (0.38) | ADRA2AANO1TP53MAPTPDK1 | |
| SCHEMBL26705459 | 0.69 | ANO1 (0.40) | ADRA2AANO1SMN1; SMN2TP53MAPT | |
| SCHEMBL7490063 | 0.69 | PTGES (0.41) | SMN1; SMN2MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5914342-A | 2-imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists | THE PROCTER & GAMBLE COMPANY (US) | 1999-06-22 | — | — | US | disclosed |