Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Monoctanoin Component A. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.88 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.88 |
| ▸ | MEN1 | O00255 | 1/20 | 0.88 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.88 |
| ▸ | LMNA | P02545 | 1/20 | 0.88 |
| ▸ | DGKA | P23743 | 1/20 | 0.74 |
| ▸ | LPAR1 | Q92633 | 7/20 | 0.71 |
| ▸ | ENPP2 | Q13822 | 6/20 | 0.71 |
| ▸ | LPAR4 | Q99677 | 4/20 | 0.71 |
| ▸ | LPAR2 | Q9HBW0 | 4/20 | 0.71 |
| ▸ | LPAR3 | Q9UBY5 | 4/20 | 0.71 |
| ▸ | LPAR5 | Q9H1C0 | 3/20 | 0.71 |
| ▸ | LPAR6 | P43657 | 2/20 | 0.71 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.66 |
| ▸ | FAAH | O00519 | 2/20 | 0.62 |
| ▸ | CES2 | O00748 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL28261779 | 1.00 | KDM4E (0.88) | KDM4EDUSP3MEN1KMT2ALMNA | |
| Glyceryl Monostearate SCHEMBL7999761 | 1.00 | KDM4E (0.88) | KDM4EDUSP3MEN1KMT2ALMNA | |
| Glyceryl Monostearate SCHEMBL29144673 | 0.98 | KDM4E (0.85) | KDM4EDUSP3MEN1KMT2ALMNA | |
| SCHEMBL2326840 | 0.94 | LMNA (1.00) | KDM4EDUSP3MEN1KMT2ALMNA | |
| SCHEMBL10937708 | 0.94 | LMNA (1.00) | KDM4EDUSP3MEN1KMT2ALMNA | |
| Glycerol Monopalmitate SCHEMBL977143 | 0.94 | LMNA (1.00) | KDM4EDUSP3MEN1KMT2ALMNA | |
| SCHEMBL2119138 | 0.94 | LMNA (1.00) | KDM4EDUSP3MEN1KMT2ALMNA | |
| Glyceryl Monostearate SCHEMBL1653474 | 0.94 | LMNA (1.00) | KDM4EDUSP3MEN1KMT2ALMNA | |
| Glyceryl Monostearate SCHEMBL4488 | 0.94 | LMNA (1.00) | KDM4EDUSP3MEN1KMT2ALMNA | |
| SCHEMBL2508008 | 0.94 | LMNA (1.00) | KDM4EDUSP3MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160324762-A1 | DARK CIRCLE CORRECTING AND CONCEALING COMPOSITIONS | MAKEFIELD LLC | 2016-11-10 | — | — | US | disclosed |
| EP-0927019-A1 | COMPOSITIONS FOR COSMETIC APPLICATIONS | MedLogic Global Corporation (US) | 1999-07-07 | — | — | EP | disclosed |
| WO-1998048768-A1 | COMPOSITIONS FOR COSMETIC APPLICATIONS | MEDLOGIC GLOBAL CORPORATION (US) | 1998-11-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160324762-A1 | DARK CIRCLE CORRECTING AND CONCEALING COMPOSITIONS | CUTA, ERCC5, ERCC4 | KDM4E 458/4885DUSP3 3519/4885MEN1 2449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.