Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | GALR2 | O43603 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | KLF10 | Q13118 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.33 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | PGK1 | P00558 | 1/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11834724 | 0.74 | LMNA (0.66) | LMNAGALR2POLBSMN1; SMN2PTPN1 | |
| SCHEMBL265579 | 0.73 | KDM4E (0.38) | LMNAPOLBKDM4ERAB9AMAPT | |
| SCHEMBL1896687 | 0.72 | MAT2A (0.37) | SMN1; SMN2KDM4EALDH1A1PKMMAT2A | |
| SCHEMBL18325718 | 0.72 | MAT2A (0.37) | LMNASMN1; SMN2MAPTALDH1A1MAT2A | |
| SCHEMBL3797103 | 0.71 | MAT2A (0.36) | MAT2A | |
| SCHEMBL8728438 | 0.70 | PKM (0.37) | PKMTSHRHSD17B10 | |
| SCHEMBL11715435 | 0.68 | GALR2 (0.58) | LMNAGALR2POLBSMN1; SMN2RAB9A | |
| SCHEMBL18132314 | 0.68 | KMT2A (0.35) | MAT2A | |
| SCHEMBL18610783 | 0.67 | MAT2A (0.33) | MAT2ACYP3A4HSD17B10 | |
| SCHEMBL5288789 | 0.67 | LMNA (0.51) | LMNAGALR2POLBSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673938-B1 | Purine derivatives and pharmaceutically acceptable salts thereof | NIPPON ZOKI PHARMACEUTICAL CO (JP) | 1999-07-07 | — | — | EP | disclosed |
| US-5658918-A | INHIBITING NASAL MUCOUS SECRETION | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1997-08-19 | — | — | US | disclosed |
| EP-0673938-A2 | Novel purine derivatives and pharmaceutically acceptable salts thereof | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1995-09-27 | — | — | EP | disclosed |