SCHEMBL265579

SCHEMBL265579

Nc1nc(=O)[nH]cc1[N+](=O)[O-]

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.38
RAB9A P51151 1/20 0.36
MAPT P10636 6/20 0.36
CYP3A4 P08684 2/20 0.34
TSHR P16473 2/20 0.34
HPGD P15428 2/20 0.34
GRIN2D O15399 1/20 0.34
GRIN3B O60391 1/20 0.34
LMNA P02545 1/20 0.34
CYP1A2 P05177 1/20 0.34
GRIK1 P39086 1/20 0.34
GRIA1 P42261 1/20 0.34
GRIA2 P42262 1/20 0.34
GRIA3 P42263 1/20 0.34
GRIA4 P48058 1/20 0.34
BLM P54132 1/20 0.34
GRIN1 Q05586 1/20 0.34
GRIN2A Q12879 1/20 0.34
GRIK2 Q13002 1/20 0.34
GRIK3 Q13003 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Flucytosine SCHEMBL3868994 0.73 RXFP1 (0.36) RXFP1
SCHEMBL8405047 0.73 LMNA (0.50) KDM4ERAB9AMAPTCYP3A4TSHR
SCHEMBL3585568 0.71
SCHEMBL597893 0.70 TDP1 (0.50) MAPTCYP3A4TSHRLMNACYP1A2
SCHEMBL5143009 0.70
SCHEMBL1231792 0.67 ATAD2 (0.37) CYP1A2
SCHEMBL22008 0.67
Flucytosine SCHEMBL8160959 0.67 ALDH1A1 (0.37) MAPTTSHRLMNAALDH1A1
SCHEMBL1765946 0.67
SCHEMBL30609151 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 473 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250066799-A1 UNNATURAL BASE PAIR COMPOSITIONS AND METHODS OF USE THE SCRIPPS RESEARCH INSTITUTE 2025-02-27 US claimed
CN-112105627-B Unnatural base pair compositions and methods of use 斯克利普斯研究所 2024-07-02 CN claimed
US-20230235339-A1 IMPORT OF UNNATURAL OR MODIFIED NUCLEOSIDE TRIPHOSPHATES INTO CELLS VIA NUCLEIC ACID TRIPHOSPHATE TRANSPORTERS THE SCRIPPS RESEARCH INSTITUTE 2023-07-27 US claimed
EP-4041249-A1 COMPOSITIONS AND METHODS FOR IN VIVO SYNTHESIS OF UNNATURAL POLYPEPTIDES The Scripps Research Institute (US) 2022-08-17 EP claimed
US-20220243244-A1 COMPOSITIONS AND METHODS FOR IN VIVO SYNTHESIS OF UNNATURAL POLYPEPTIDES NATIONAL INSTITUTES OF HEALTH 2022-08-04 US claimed
CN-114761026-A Compositions and methods for in vivo synthesis of non-native polypeptides 斯克利普斯研究所 2022-07-15 CN claimed
WO-2021072167-A1 COMPOSITIONS AND METHODS FOR IN VIVO SYNTHESIS OF UNNATURAL POLYPEPTIDES THE SCRIPPS RESEARCH INSTITUTE (US) 2021-04-15 WO claimed
CN-112105627-A Non-natural base pair compositions and methods of use 斯克利普斯研究所 2020-12-18 CN claimed
EP-3732187-A1 UNNATURAL BASE PAIR COMPOSITIONS AND METHODS OF USE The Scripps Research Institute (US) 2020-11-04 EP claimed
US-20200318122-A1 UNNATURAL BASE PAIR COMPOSITIONS AND METHODS OF USE THE SCRIPPS RESEARCH INSTITUTE 2020-10-08 US claimed
WO-2016115168-A1 INCORPORATION OF UNNATURAL NUCLEOTIDES AND METHODS THEREOF Synthorx, Inc. (US) 2016-07-21 WO claimed
WO-2015157555-A2 IMPORT OF UNNATURAL OR MODIFIED NUCLEOSIDE TRIPHOSPHATES INTO CELLS VIA NUCLEIC ACID TRIPHOSPHATE TRANSPORTERS THE SCRIPPS RESEARCH INSTITUTE (US) 2015-10-15 WO claimed
US-8133669-B2 Chemically modified nucleoside 5′-triphosphates for thermally initiated amplification of nucleic acid TRILINK BIOTECHNOLOGIES (US) 2012-03-13 US claimed
EP-2294076-A1 CHEMICALLY MODIFIED NUCLEOSIDE 5'-TRIPHOSPHATES FOR THERMALLY INITIATED AMPLIFICATION OF NUCLEIC ACID TriLink BioTechnologies (US) 2011-03-16 EP claimed
US-20100003724-A1 CHEMICALLY MODIFIED NUCLEOSIDE 5'-TRIPHOSPHATES FOR THERMALLY INITIATED AMPLIFICATION OF NUCLEIC ACID TriLink Bio Technologies 2010-01-07 US claimed
WO-2009151921-A1 CHEMICALLY MODIFIED NUCLEOSIDE 5'-TRIPHOSPHATES FOR THERMALLY INITIATED AMPLIFICATION OF NUCLEIC ACID TRILINK BIOTECHNOLOGIES (US) 2009-12-17 WO claimed
US-20090149411-A1 IMMUNOSTIMULATORY OLIGONUCLEOTIDES WITH MODIFIED BASES AND METHODS OF USE THEREOF DYNAVAX TECHNOLOGIES CORPORATION 2009-06-11 US claimed
US-20040092468-A1 Immunostimulatory oligonucleotides with modified bases and methods of use thereof SCHWARTZ DAVID (US) 2004-05-13 US claimed
EP-1121373-A2 IMMUNOSTIMULATORY OLIGONUCLEOTIDES WITH MODIFIED BASES AND METHODS OF USE THEREOF Dynavax Technologies Corporation (US) 2001-08-08 EP claimed
WO-1999062923-A2 IMMUNOSTIMULATORY OLIGONUCLEOTIDES WITH MODIFIED BASES AND METHODS OF USE THEREOF DYNAVAX TECHNOLOGIES CORPORATION (US) 1999-12-09 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230235339-A1 IMPORT OF UNNATURAL OR MODIFIED NUCLEOSIDE TRIPHOSPHATES INTO CELLS VIA NUCLEIC ACID TRIPHOSPHATE TRANSPORTERS NUDT1, UPP1, UMPS KDM4E 4290/4885RAB9A 2218/4885MAPT 852/4885
US-20250066799-A1 UNNATURAL BASE PAIR COMPOSITIONS AND METHODS OF USE RNGTT, SPOUT1, NPEPPS KDM4E 4046/4885RAB9A 2910/4885MAPT 3580/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.