SCHEMBL84053

SCHEMBL84053

Cc1ccc(C)c(C(F)(F)F)c1

nearest known ligand 0.44

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.44
TDP1 Q9NUW8 2/20 0.42
ALDH1A1 P00352 1/20 0.42
SYK P43405 1/20 0.42
NOTUM Q6P988 1/20 0.41
S1PR1 P21453 3/20 0.40
AR P10275 3/20 0.40
TAS2R14 Q9NYV8 1/20 0.39
KIF11 P52732 1/20 0.38
ALKBH5 Q6P6C2 1/20 0.38
PDE3B Q13370 1/20 0.38
PDE3A Q14432 1/20 0.38
CYP1A2 P05177 2/20 0.38
CYP2A6 P11509 2/20 0.38
TP53 P04637 1/20 0.37
RAPGEF4 Q8WZA2 1/20 0.37
FFAR4 Q5NUL3 1/20 0.37
CTSS P25774 1/20 0.36
CTSK P43235 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10328480 0.83 SMN1; SMN2 (0.42) SMN1; SMN2TDP1ALDH1A1SYKKIF11
SCHEMBL23029423 0.83 SMN1; SMN2 (0.42) SMN1; SMN2TDP1ALDH1A1SYKKIF11
SCHEMBL17297890 0.82 AR (0.61) ALDH1A1NOTUMS1PR1ARKIF11
SCHEMBL4273522 0.82 SMN1; SMN2 (0.45) SMN1; SMN2TDP1SYKNOTUMAR
SCHEMBL15607697 0.81 SMN1; SMN2 (0.46) SMN1; SMN2TDP1ALDH1A1SYKAR
SCHEMBL15957611 0.81 SMN1; SMN2 (0.50) SMN1; SMN2TDP1ALDH1A1SYKCYP1A2
SCHEMBL13475912 0.81 SMN1; SMN2 (0.46) SMN1; SMN2TDP1ALDH1A1SYKAR
SCHEMBL5949403 0.80 NOTUM (0.53) NOTUMS1PR1ARTAS2R14KIF11
SCHEMBL144686 0.80 TP53 (0.42) SMN1; SMN2TDP1ALDH1A1SYKAR
SCHEMBL10030392 0.80 GLA (0.54) SMN1; SMN2SYKARKIF11PDE3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 639 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240224783-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2024-07-04 US disclosed
US-20240218004-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2024-07-04 US disclosed
US-20240224782-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2024-07-04 US disclosed
US-20240209013-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2024-06-27 US disclosed
WO-2024044757-A1 AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS Sanford Burnham Prebys Medical Discovery Institute (US) 2024-02-29 WO disclosed
US-20240023435-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2024-01-18 US disclosed
US-20230399350-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-12-14 US disclosed
US-20230371358-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-11-16 US disclosed
US-20230365606-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-11-16 US disclosed
US-20230357296-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-11-09 US disclosed
US-20070042997-A1 Medicament for treatment of dermal pigmentation INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) 2007-02-22 US disclosed
US-7179840-B2 Furancarboxamides BAYER CROPSCIENCE AG (DE) 2007-02-20 US disclosed
US-7179840-B2 Furancarboxamides BAYER CROPSCIENCE AG (DE) 2007-02-20 US disclosed
US-7176214-B2 Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same BRISTOL-MYERS SQUIBB COMPANY (US) 2007-02-13 US disclosed
US-7176214-B2 Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same BRISTOL-MYERS SQUIBB COMPANY (US) 2007-02-13 US disclosed
US-20060094739-A1 3-Aryl-3-hydroxy-2-methylenepropionic acid esters as fungicides ATP CAPITAL LP 2006-05-04 US disclosed
WO-2006044454-A1 1-(HETERO)ARYL-3-AMINO-PYROLLIDINE DERIVATIVES FOR USE AS MGLUR3 RECEPTOR ANTAGONISTS ELI LILLY AND COMPANY (US) 2006-04-27 WO disclosed
EP-0084648-B1 PROCESS FOR THE ISOMERIZATION OF ALKYLBENZOTRIFLUORIDES BAYER AG (DE) 1984-11-07 EP disclosed
US-4436941-A Process for the isomerization of alkylbenzotrifluorides BAYER AKTIENGESELLSCHAFT (DE) 1984-03-13 US disclosed
EP-0084648-A1 Process for the isomerization of alkylbenzotrifluorides BAYER AG (DE) 1983-08-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230399350-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD1, OCIAD2, OSBP SMN1; SMN2 4056/4885TDP1 1010/4885ALDH1A1 504/4885
US-20230357296-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OPRD1, OXER1, LBR SMN1; SMN2 3071/4885TDP1 3793/4885ALDH1A1 1046/4885
US-20240224783-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD2, OCIAD1, ICOSLG SMN1; SMN2 4481/4885TDP1 3894/4885ALDH1A1 149/4885
US-20240209013-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD2, SSB, L1CAM SMN1; SMN2 2241/4885TDP1 3938/4885ALDH1A1 419/4885
US-20070042997-A1 Medicament for treatment of dermal pigmentation TYR, XDH, XPA SMN1; SMN2 4614/4885TDP1 2714/4885ALDH1A1 140/4885
US-20230371358-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES LIFR, SOD1, ROS1 SMN1; SMN2 3772/4885TDP1 4776/4885ALDH1A1 569/4885
US-20230365606-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OXER1, OPRD1, OXSR1 SMN1; SMN2 3270/4885TDP1 4382/4885ALDH1A1 728/4885
US-20240224782-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES RER1, OCIAD2, OCIAD1 SMN1; SMN2 2441/4885TDP1 3643/4885ALDH1A1 617/4885
US-20240218004-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD1, OCIAD2, CCND2 SMN1; SMN2 3374/4885TDP1 4206/4885ALDH1A1 497/4885
US-20060094739-A1 3-Aryl-3-hydroxy-2-methylenepropionic acid esters as fungicides CYP51A1, DDT, CYP21A2 SMN1; SMN2 1516/4885TDP1 2148/4885ALDH1A1 62/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.