Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.69 |
| ▸ | TP53 | P04637 | 3/20 | 0.69 |
| ▸ | HTT | P42858 | 3/20 | 0.69 |
| ▸ | NPC1 | O15118 | 3/20 | 0.69 |
| ▸ | RAB9A | P51151 | 3/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.69 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.69 |
| ▸ | RELA | Q04206 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 5/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | PNLIP | P16233 | 5/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | PLG | P00747 | 2/20 | 0.57 |
| ▸ | PLAU | P00749 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13523838 | 0.86 | LMNA (0.63) | LMNATP53HTTNPC1RAB9A | |
| SCHEMBL2913097 | 0.86 | LMNA (0.66) | LMNATP53HTTNPC1RAB9A | |
| SCHEMBL18327174 | 0.86 | LMNA (0.89) | LMNATP53HTTNPC1RAB9A | |
| SCHEMBL28952582 | 0.84 | ALDH1A1 (0.69) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL17660206 | 0.84 | HPGD (0.70) | LMNAHTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2915874 | 0.84 | LMNA (0.60) | LMNATP53HTTNPC1RAB9A | |
| SCHEMBL18503022 | 0.83 | MEN1 (0.75) | LMNATP53HTTNPC1RAB9A | |
| SCHEMBL2577563 | 0.83 | FADS1 (0.72) | TP53NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL21620314 | 0.83 | MEN1 (0.68) | LMNATP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6810850 | 0.81 | LMNA (0.74) | LMNATP53HTTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5905090-A | IMMUNOSUPPRESSANTS AND/OR ANTIINFLAMMATORIES | ITALFARMACO S.P.A. (IT) | 1999-05-18 | — | — | US | disclosed |