SCHEMBL8405441

SCHEMBL8405441

Oc1cc(Cl)c(OCCc2ccccc2)c(Cl)c1

nearest known ligand 0.49

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 1/20 0.42
ADRA1D P25100 1/20 0.42
ADRA1A P35348 1/20 0.42
ADRA1B P35368 1/20 0.42
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
FFAR1 O14842 2/20 0.41
ESR1 P03372 1/20 0.41
ESR2 Q92731 1/20 0.41
PLAU P00749 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
PDE4D Q08499 1/20 0.39
MEN1 O00255 1/20 0.39
ALDH1A1 P00352 1/20 0.39
MAPK1 P28482 1/20 0.39
KMT2A Q03164 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8408825 0.92 IDO1 (0.46) HTR1AADRA1DADRA1AADRA1BFFAR1
SCHEMBL8405941 0.90 IGF1R (0.45) FFAR1L3MBTL1
SCHEMBL8408802 0.89 GPR84 (0.46) FFAR1L3MBTL1
SCHEMBL8407191 0.89 GPR84 (0.46) FFAR1L3MBTL1
SCHEMBL8405539 0.88 PPARG (0.47) FFAR1
SCHEMBL8408738 0.87 DRD2 (0.47)
SCHEMBL8408534 0.86 IGF1R (0.42) MEN1MAPK1KMT2A
SCHEMBL8405517 0.85 TAAR1 (0.46)
SCHEMBL8405357 0.85 SLC5A1 (0.43) NPC1RAB9AMEN1KMT2A
SCHEMBL8405763 0.84 LMNA (0.50) HTR1AADRA1DADRA1AADRA1BNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5872137-A AROMATIC OXY DIHALOPRENE COMPOUNDS INSECTICIDAL/ACARICIDAL AGENTS CONTAINING SAME, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-02-16 US disclosed
EP-0722430-B1 DIHALOPROPENE COMPOUNDS, INSECTICIDAL/ACARICIDAL AGENTS CONTAINING SAME, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL CO (JP) 1998-10-21 EP disclosed
EP-0722430-A1 DIHALOPROPENE COMPOUNDS, INSECTICIDAL/ACARICIDAL AGENTS CONTAINING SAME, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1996-07-24 EP disclosed
WO-1996004228-A1 DIHALOPROPENE COMPOUNDS, INSECTICIDAL/ACARICIDAL AGENTS CONTAINING SAME, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-02-15 WO disclosed