Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | USP9X | Q93008 | 2/20 | 0.37 |
| ▸ | CTH | P32929 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 2/20 | 0.36 |
| ▸ | CCND1 | P24385 | 2/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL840646 | 1.00 | ALDH1A1 (0.39) | ALDH1A1TRPA1LMNAALOX5MAPK1 | |
| SCHEMBL8772140 | 0.92 | USP9X (0.35) | ALDH1A1TRPA1LMNAALOX5MAPK1 | |
| SCHEMBL8892427 | 0.92 | USP9X (0.35) | ALDH1A1TRPA1LMNAALOX5MAPK1 | |
| SCHEMBL104173 | 0.79 | — | — | |
| SCHEMBL29792032 | 0.79 | — | — | |
| SCHEMBL2553909 | 0.76 | ALDH1A1 (0.56) | ALDH1A1TRPA1LMNAALOX5MAPK1 | |
| SCHEMBL2553913 | 0.76 | ALDH1A1 (0.56) | ALDH1A1TRPA1LMNAALOX5MAPK1 | |
| SCHEMBL22032508 | 0.76 | NPC1 (0.64) | ALDH1A1MAPK1MEN1NPC1KMT2A | |
| SCHEMBL28968606 | 0.76 | NFE2L2 (0.50) | ALDH1A1TRPA1LMNAALOX5MAPK1 | |
| SCHEMBL31638135 | 0.76 | NFE2L2 (0.50) | ALDH1A1TRPA1LMNAALOX5MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9000179-B2 | Inhibitors of proliferation and activation of signal transducer and activator of transcription (STATs) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2015-04-07 | — | — | US | disclosed |
| EP-2307367-B1 | NOVEL INHIBITORS OF PROLIFERATION AND ACTIVATION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION (STATS) | UNIV TEXAS (US) | 2014-09-24 | — | — | EP | disclosed |
| US-20140228414-A1 | NOVEL INHIBITORS OF PROLIFERATION AND ACTIVATION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION (STATS) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2014-08-14 | — | — | US | disclosed |
| EP-2480554-B1 | MACROCYCLIC INHIBITORS OF JAK | HOFFMANN LA ROCHE (CH) | 2014-08-06 | — | — | EP | disclosed |
| US-8637675-B2 | Inhibitors of proliferation and activation of signal transducer and activators of transcription (STATS) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2014-01-28 | — | — | US | disclosed |
| US-8318764-B2 | Macrocyclic inhibitors of JAK | ROCHE PALO ALTO LLC (US) | 2012-11-27 | — | — | US | disclosed |
| US-8318764-B2 | Macrocyclic inhibitors of JAK | ROCHE PALO ALTO LLC (US) | 2012-11-27 | — | — | US | disclosed |
| US-20120149738-A1 | NOVEL INHIBITORS OF PROLIFERATION AND ACTIVATION OF SIGNAL TRANSDUCER AND ACTIVATORS OF TRANSCRIPTION (STATS) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2012-06-14 | — | — | US | disclosed |
| US-8143412-B2 | Inhibitors of proliferation and activation of signal transducer and activator of transcription (STATs) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2012-03-27 | — | — | US | disclosed |
| CN-102143947-A | Novel inhibitors of proliferation and activation of signal transduction and transcriptional activator proteins | UNIV TEXAS | 2011-08-03 | — | — | CN | disclosed |
| WO-2011033053-A1 | MACROCYCLIC INHIBITORS OF JAK | F. HOFFMANN-LA ROCHE AG (CH) | 2011-03-24 | — | — | WO | disclosed |
| US-20110071179-A1 | MACROCYCLIC INHIBITORS OF JAK | JAHANGIR ALAM | 2011-03-24 | — | — | US | disclosed |
| US-20110071179-A1 | MACROCYCLIC INHIBITORS OF JAK | JAHANGIR ALAM | 2011-03-24 | — | — | US | disclosed |
| US-20110053992-A1 | Novel Inhibitors of Proliferation and Activation of Signal Transducer and Activator of Transcription (STATS) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2011-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053992-A1 | Novel Inhibitors of Proliferation and Activation of Signal Transducer and Activator of Transcription (STATS) | STAT5A, STAT3, STAT5B | ALDH1A1 2934/4885TRPA1 3097/4885LMNA 4620/4885 |
| US-20140228414-A1 | NOVEL INHIBITORS OF PROLIFERATION AND ACTIVATION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION (STATS) | STAT5A, STAT3, STAT5B | ALDH1A1 2934/4885TRPA1 3097/4885LMNA 4620/4885 |
| US-20120149738-A1 | NOVEL INHIBITORS OF PROLIFERATION AND ACTIVATION OF SIGNAL TRANSDUCER AND ACTIVATORS OF TRANSCRIPTION (STATS) | STAT3, STAT5A, STAT5B | ALDH1A1 3017/4885TRPA1 3043/4885LMNA 4613/4885 |
| US-20110071179-A1 | MACROCYCLIC INHIBITORS OF JAK | JAK2, JAK1, JAK3 | ALDH1A1 4261/4885TRPA1 4484/4885LMNA 4748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.