SCHEMBL8406891

SCHEMBL8406891

CC(=CC[Si](C)(C)c1ccccc1)C(=O)O

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.57
AKR1C3 P42330 1/20 0.44
RXRA P19793 1/20 0.41
RXRB P28702 1/20 0.41
NR4A2 P43354 1/20 0.41
RXRG P48443 1/20 0.41
CYP2C9 P11712 1/20 0.39
ESR1 P03372 1/20 0.37
ESR2 Q92731 1/20 0.37
CES2 O00748 1/20 0.35
CES1 P23141 1/20 0.35
RECQL P46063 1/20 0.35
APEX1 P27695 7/20 0.35
ALDH1A1 P00352 2/20 0.35
LMNA P02545 1/20 0.35
PPARG P37231 1/20 0.35
HTT P42858 1/20 0.34
MTNR1A P48039 1/20 0.34
MTNR1B P49286 1/20 0.34
NR1H2 P55055 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8357936 0.83 MAPT (0.54) MAPTAKR1C3RXRARXRBNR4A2
SCHEMBL3780444 0.77 MAPT (0.47) MAPTAKR1C3RXRARXRBNR4A2
SCHEMBL3780762 0.77 MAPT (0.47) MAPTAKR1C3RXRARXRBNR4A2
SCHEMBL3785121 0.75 MAPT (0.45) MAPTAKR1C3RXRARXRBNR4A2
SCHEMBL5852502 0.72 HPGD (0.43) MAPTAKR1C3PPARG
SCHEMBL399700 0.72 HPGD (0.43) MAPTAKR1C3PPARG
SCHEMBL3293184 0.72 MAPT (0.49) MAPTAKR1C3RXRARXRBNR4A2
SCHEMBL3787971 0.72 MAPT (0.49) MAPTAKR1C3RXRARXRBNR4A2
SCHEMBL3786632 0.70 MAPT (0.41) MAPTAKR1C3RXRARXRBNR4A2
SCHEMBL8063878 0.70 MAPT (0.41) MAPTAKR1C3RXRARXRBNR4A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0727450-B1 Liquid toners with hydrocarbon solvents MINNESOTA MINING & MFG (US) 1999-07-21 EP disclosed
US-5753763-A Process for preparing liquid toners with hydrocarbon solvents MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1998-05-19 US disclosed
US-5663024-A Liquid toners with hydrocarbon solvents MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1997-09-02 US disclosed
US-5604070-A Liquid toners with hydrocarbon solvents MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1997-02-18 US disclosed
US-5599886-A Liquid toners with hydrocarbon solvents MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1997-02-04 US disclosed
EP-0727450-A1 Liquid toners with hydrocarbon solvents MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1996-08-21 EP disclosed
US-5521271-A Liquid toners with hydrocarbon solvents MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1996-05-28 US disclosed
EP-0706095-A1 Liquid toners with hydrocarbon solvents MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1996-04-10 EP disclosed