SCHEMBL3787971

SCHEMBL3787971

CC(=C[Si](C)(c1ccccc1)c1ccccc1)C(=O)O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.49
AKR1C3 P42330 1/20 0.48
RXRA P19793 1/20 0.41
RXRB P28702 1/20 0.41
NR4A2 P43354 1/20 0.41
RXRG P48443 1/20 0.41
CES2 O00748 1/20 0.39
CES1 P23141 1/20 0.39
CYP2C9 P11712 1/20 0.39
APEX1 P27695 8/20 0.38
HTT P42858 1/20 0.37
ESR1 P03372 1/20 0.36
ESR2 Q92731 1/20 0.36
HPGD P15428 1/20 0.36
GLA P06280 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
ALDH1A1 P00352 1/20 0.35
DAO P14920 1/20 0.34
TSHR P16473 1/20 0.34
NAPRT Q6XQN6 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3293184 0.84 MAPT (0.49) MAPTAKR1C3RXRARXRBNR4A2
SCHEMBL3297070 0.82 AKR1C3 (0.50) MAPTAKR1C3RXRARXRBNR4A2
SCHEMBL5144091 0.82 AKR1C3 (0.50) MAPTAKR1C3RXRARXRBNR4A2
SCHEMBL17420014 0.79 AKR1C3 (0.44) MAPTAKR1C3RXRARXRBNR4A2
SCHEMBL560335 0.76 AKR1C3 (0.44) MAPTAKR1C3RXRARXRBNR4A2
SCHEMBL4917439 0.76 AKR1C3 (0.44) MAPTAKR1C3RXRARXRBNR4A2
SCHEMBL3782395 0.74 CYP2C9 (0.45) MAPTCYP2C9HPGDTDP1ALDH1A1
SCHEMBL6357912 0.74 MAPT (0.41) MAPTAKR1C3RXRARXRBNR4A2
SCHEMBL3783448 0.73 CYP2C9 (0.47) MAPTAKR1C3CYP2C9HPGDTDP1
SCHEMBL3782444 0.72 CYP2C9 (0.46) MAPTAKR1C3RXRARXRBNR4A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100183540-A1 BRANCHED POLYMER AND ANTIFOULING COATING COMPOSITION COMPRISING THE POLYMER JOTUN A/S (NO) 2010-07-22 US disclosed
US-7297727-B2 Triarylsilyl(meth)acryloyl-containing polymers for marine coating compositions ARKEMA INC. (US) 2007-11-20 US disclosed
US-20060189708-A1 Benzylsilyl(meth)acryloyl-containing polymers for marine coating compositions ARKEMA INC. 2006-08-24 US disclosed
EP-1479737-B1 Triarylsilyl(meth)acryloyl-containing polymers for marine coating compositions ARKEMA INC (US) 2006-08-16 EP disclosed
WO-2005110440-A1 STABILIZERS FOR HYDROLYZABLE ORGANIC BINDERS ARKEMA, INC. (US) 2005-11-24 WO disclosed
WO-2005111133-A2 STABILIZED ENVIRONMENTALLY SENSITIVE BINDERS ARKEMA INC. (US) 2005-11-24 WO disclosed
US-20050256235-A1 Stabilized environmentally sensitive binders ARKEMA INC. 2005-11-17 US disclosed
US-20050255081-A1 Stabilizers for hydrolyzable organic binders ARKEMA INC. 2005-11-17 US disclosed
EP-1479737-A1 Triarylsilyl(meth)acryloyl-containing polymers for marine coating compositions Atofina Chemicals, Inc. (US) 2004-11-24 EP disclosed
US-20040138332-A1 Triarylsilyl(meth)acryloyl-containing polymers for marine coating compositions ARKEMA INC. 2004-07-15 US disclosed
US-20030225184-A1 Triarylsilyl(meth)acryloyl-containing polymers for marine coating compositions ARKEMA INC. 2003-12-04 US disclosed
EP-1367100-A1 Triarylsilyl (meth) acryloyl-containing polymers for marine coating compositions ATOFINA CHEMICALS, INC. (US) 2003-12-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050255081-A1 Stabilizers for hydrolyzable organic binders ALKBH2, PHOSPHO1, ALKBH1 MAPT 1438/4885AKR1C3 3137/4885RXRA 4859/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.