Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8409922 | 0.79 | CYP1A2 (0.47) | — | |
| SCHEMBL8408962 | 0.77 | MTNR1A (0.59) | — | |
| SCHEMBL8409903 | 0.76 | ADRA1A (0.60) | ADRA1ADRD2DRD3NR2E1HTR1D | |
| SCHEMBL8406932 | 0.76 | ADRA1A (0.60) | ADRA1ADRD2DRD3NR2E1HTR1D | |
| SCHEMBL8407080 | 0.75 | MTNR1A (0.61) | — | |
| SCHEMBL8409531 | 0.74 | MTNR1A (0.61) | — | |
| SCHEMBL8406946 | 0.74 | MTNR1A (0.44) | — | |
| SCHEMBL6959304 | 0.70 | ADRA1A (0.47) | ADRA1ADRD2DRD3HTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL6951794 | 0.69 | ADRA1A (0.46) | ADRA1ADRD2DRD3HTR1DHTR1B | |
| SCHEMBL10618504 | 0.69 | ADRA1A (0.54) | ADRA1ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0737670-B1 | Tricyclic amides, processes for their preparation, and pharmaceutical compositions containing them | ADIR (FR) | 1999-07-21 | — | — | EP | disclosed |
| US-5849781-A | Tricyclic amides | ADIR ET COMPAGNIE (FR) | 1998-12-15 | — | — | US | disclosed |
| US-5712312-A | MELATONINERGIC RECEPTOR LIGANDS, TREATMENT OF SLEEP DISORDERS | ADIR ET COMPAGNIE (FR) | 1998-01-27 | — | — | US | disclosed |
| EP-0737670-A1 | Tricyclic amides, processes for their preparation, and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-10-16 | — | — | EP | disclosed |