Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 3/20 | 0.60 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8406932 | 0.94 | ADRA1A (0.60) | ADRA1ADRD2DRD3ALDH1A1MAPT | |
| SCHEMBL24734855 | 0.76 | ADRA1A (1.00) | ADRA1ADRD2DRD3HTR1DHTR1B | |
| SCHEMBL8406908 | 0.76 | ADRA1A (0.48) | ADRA1ADRD2DRD3NR2E1HTR1D | |
| SCHEMBL8409648 | 0.76 | MTNR1A (0.59) | ALDH1A1MAPTNPSR1 | |
| Hydrochloric Acid SCHEMBL8669188 | 0.75 | ADRA1A (0.96) | ADRA1ADRD2DRD3HTR1DHTR1B | |
| Bromide SCHEMBL25243558 | 0.75 | ADRA1A (0.96) | ADRA1ADRD2DRD3HTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL30861222 | 0.75 | ADRA1A (0.96) | ADRA1ADRD2DRD3HTR1DHTR1B | |
| SCHEMBL25246966 | 0.74 | ADRA1A (0.65) | ADRA1ADRD2DRD3HTR1DHTR1B | |
| SCHEMBL30510677 | 0.74 | ADRA1A (0.65) | ADRA1ADRD2DRD3HTR1DHTR1B | |
| SCHEMBL8409684 | 0.73 | CYP1A2 (0.57) | ALDH1A1MAPTNPSR1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0737670-B1 | Tricyclic amides, processes for their preparation, and pharmaceutical compositions containing them | ADIR (FR) | 1999-07-21 | — | — | EP | disclosed |
| US-5849781-A | Tricyclic amides | ADIR ET COMPAGNIE (FR) | 1998-12-15 | — | — | US | disclosed |
| US-5712312-A | MELATONINERGIC RECEPTOR LIGANDS, TREATMENT OF SLEEP DISORDERS | ADIR ET COMPAGNIE (FR) | 1998-01-27 | — | — | US | disclosed |
| EP-0737670-A1 | Tricyclic amides, processes for their preparation, and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-10-16 | — | — | EP | disclosed |