Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.38 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8407080 | 0.81 | MTNR1A (0.61) | CYP1A2KDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL8408962 | 0.81 | MTNR1A (0.59) | CYP1A2MAPTMTNR1AMTNR1B | |
| SCHEMBL8406956 | 0.79 | MTNR1A (0.56) | CYP1A2KDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL8406908 | 0.79 | ADRA1A (0.48) | — | |
| SCHEMBL8409684 | 0.79 | CYP1A2 (0.57) | CYP1A2KDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL8409531 | 0.78 | MTNR1A (0.61) | CYP1A2MAPTMTNR1AMTNR1B | |
| SCHEMBL8352739 | 0.78 | CYP1A2 (0.56) | CYP1A2EPHX2 | |
| SCHEMBL8408690 | 0.78 | ALDH1A1 (0.41) | KDM4EALDH1A1HPGDNPSR1GLA | |
| SCHEMBL8406946 | 0.77 | MTNR1A (0.44) | CYP1A2KDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL10622279 | 0.72 | CYP1A2 (0.52) | CYP1A2EPHX2MTNR1AMTNR1BAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0737670-B1 | Tricyclic amides, processes for their preparation, and pharmaceutical compositions containing them | ADIR (FR) | 1999-07-21 | — | — | EP | disclosed |
| US-5849781-A | Tricyclic amides | ADIR ET COMPAGNIE (FR) | 1998-12-15 | — | — | US | disclosed |
| US-5712312-A | MELATONINERGIC RECEPTOR LIGANDS, TREATMENT OF SLEEP DISORDERS | ADIR ET COMPAGNIE (FR) | 1998-01-27 | — | — | US | disclosed |
| EP-0737670-A1 | Tricyclic amides, processes for their preparation, and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-10-16 | — | — | EP | disclosed |