Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.63 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.60 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.60 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.60 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.60 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.60 |
| ▸ | CNR2 | P34972 | 1/20 | 0.55 |
| ▸ | KIF11 | P52732 | 1/20 | 0.54 |
| ▸ | TGM2 | P21980 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | RORC | P51449 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3736169 | 0.87 | L3MBTL1 (0.73) | LMNAHTTEPHX2TRPV1PDK1 | |
| SCHEMBL11874552 | 0.84 | LMNA (0.64) | LMNAHTTEPHX2TRPV1PDK1 | |
| SCHEMBL20870704 | 0.82 | EPHX2 (0.70) | LMNAHTTEPHX2TRPV1KIF11 | |
| SCHEMBL3959053 | 0.80 | HTT (1.00) | LMNAHTTEPHX2TRPV1PDK1 | |
| SCHEMBL26626317 | 0.79 | EPHX2 (0.66) | LMNAHTTEPHX2TRPV1PDK1 | |
| SCHEMBL30481207 | 0.79 | LMNA (0.62) | LMNAHTTEPHX2TRPV1PDK1 | |
| SCHEMBL18086475 | 0.79 | L3MBTL1 (0.59) | HTTPDK1PDK2PDK3PDK4 | |
| SCHEMBL669442 | 0.79 | EPHX2 (0.70) | LMNAHTTEPHX2TRPV1KIF11 | |
| SCHEMBL11875212 | 0.78 | LMNA (0.57) | LMNAHTTEPHX2TRPV1PDK1 | |
| SCHEMBL10787271 | 0.78 | CNR2 (0.67) | LMNAHTTEPHX2TRPV1PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5994362-A | ADMINISTERING FINASTERIDE AND CASODEX | MERCK & CO., INC. (US) | 1999-11-30 | — | — | US | disclosed |
| EP-0514056-A2 | Use of estrogens or antiandrogens for reversal of male sexual phenotype in poultry | MERCK & CO. INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| WO-1992016233-A1 | PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF PROSTATIC CANCER CONTAINING A 5 ALPHA REDUCTASE INHIBITOR AND AN ANTIANDROGEN | MERCK & CO., INC. (US) | 1992-10-01 | — | — | WO | disclosed |