Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.43 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8409761 | 0.91 | KDM4E (0.48) | KDM4ELMNAPOLBMAPTMTNR1A | |
| SCHEMBL8410013 | 0.81 | KDM4E (0.60) | KDM4ELMNAPOLBMAPTMTNR1A | |
| SCHEMBL8409849 | 0.76 | MTNR1A (0.66) | MTNR1AMTNR1B | |
| SCHEMBL7655081 | 0.68 | LMNA (0.62) | KDM4ELMNAPOLBMAPTMTNR1A | |
| SCHEMBL8410015 | 0.68 | MTNR1A (0.62) | MTNR1AMTNR1B | |
| SCHEMBL11874244 | 0.68 | ACHE (0.78) | KDM4EMEN1KMT2AACHE | |
| SCHEMBL6633740 | 0.67 | MTNR1A (0.65) | MTNR1AMTNR1B | |
| SCHEMBL6081151 | 0.66 | CA1 (0.43) | MTNR1AMTNR1B | |
| SCHEMBL10793191 | 0.65 | MAPT (0.54) | KDM4ELMNAPOLBMAPTMTNR1A | |
| SCHEMBL6634278 | 0.63 | MTNR1A (0.69) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0737670-B1 | Tricyclic amides, processes for their preparation, and pharmaceutical compositions containing them | ADIR (FR) | 1999-07-21 | — | — | EP | disclosed |
| US-5849781-A | Tricyclic amides | ADIR ET COMPAGNIE (FR) | 1998-12-15 | — | — | US | disclosed |
| US-5712312-A | MELATONINERGIC RECEPTOR LIGANDS, TREATMENT OF SLEEP DISORDERS | ADIR ET COMPAGNIE (FR) | 1998-01-27 | — | — | US | disclosed |
| EP-0737670-A1 | Tricyclic amides, processes for their preparation, and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-10-16 | — | — | EP | disclosed |