Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | GAA | P10253 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | AKT1 | P31749 | 1/20 | 0.59 |
| ▸ | AKT2 | P31751 | 1/20 | 0.59 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6341547 | 0.96 | TDP1 (0.91) | TDP1KDM4EALDH1A1L3MBTL1LMNA | |
| SCHEMBL14733982 | 0.93 | TDP1 (0.88) | TDP1KDM4EALDH1A1L3MBTL1LMNA | |
| SCHEMBL26867246 | 0.89 | TDP1 (0.79) | TDP1KDM4EALDH1A1L3MBTL1MEN1 | |
| SCHEMBL16659834 | 0.89 | TDP1 (0.79) | TDP1KDM4EALDH1A1L3MBTL1MEN1 | |
| SCHEMBL13950894 | 0.89 | KDM4E (0.78) | TDP1KDM4EALDH1A1L3MBTL1LMNA | |
| SCHEMBL18083001 | 0.88 | ALDH1A1 (0.93) | TDP1KDM4EALDH1A1L3MBTL1LMNA | |
| SCHEMBL12595616 | 0.88 | ALDH1A1 (0.79) | TDP1KDM4EALDH1A1L3MBTL1LMNA | |
| SCHEMBL12595573 | 0.88 | ALDH1A1 (0.79) | TDP1KDM4EALDH1A1L3MBTL1LMNA | |
| SCHEMBL12146748 | 0.88 | TDP1 (0.77) | TDP1KDM4EALDH1A1L3MBTL1LMNA | |
| SCHEMBL12146746 | 0.88 | TDP1 (0.77) | TDP1KDM4EALDH1A1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105693632-B | A kind of preparation method of polysubstituted quinoxaline derivant | 华侨大学 | 2018-04-17 | — | — | CN | disclosed |
| CN-105693632-A | Preparation method of polysubstitution quinoxalin derivatives | 华侨大学 | 2016-06-22 | — | — | CN | disclosed |
| US-20160151363-A1 | Cadherin-11 Inhibitors and Methods of Use Thereof | GEORGETOWN UNIVERSITY (US) | 2016-06-02 | — | — | US | disclosed |
| US-20150064168-A1 | Cadherin-11 Inhibitors and Methods of Use Thereof | UNITED STATES GOVERNMENT | 2015-03-05 | — | — | US | disclosed |
| EP-2065378-B1 | Quinoxaline derivate, and light-emitting element, light-emitting device, and electronic device using quinoxaline derivative | SEMICONDUCTOR ENERGY LAB (JP) | 2015-01-28 | — | — | EP | disclosed |
| US-20120128693-A1 | CADHERIN-11 INHIBITORS AND METHODS OF USE THEREOF | GEORGETOWN UNIVERSITY (US) | 2012-05-24 | — | — | US | disclosed |
| EP-1342769-B1 | Organic EL Device | TDK CORP (JP) | 2010-01-27 | — | — | EP | disclosed |
| EP-1992672-A1 | Organic electroluminescent device | TDK Corporation (JP) | 2008-11-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150064168-A1 | Cadherin-11 Inhibitors and Methods of Use Thereof | CDH1, ICAM1, S100A11 | TDP1 3242/4885KDM4E 2097/4885ALDH1A1 2041/4885 |
| US-20160151363-A1 | Cadherin-11 Inhibitors and Methods of Use Thereof | CDH1, ICAM1, S100A11 | TDP1 3242/4885KDM4E 2097/4885ALDH1A1 2041/4885 |
| US-20120128693-A1 | CADHERIN-11 INHIBITORS AND METHODS OF USE THEREOF | CDH1, ICAM1, S100A11 | TDP1 3242/4885KDM4E 2097/4885ALDH1A1 2041/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.