Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 4/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.53 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.53 |
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.38 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL8408373 | 1.00 | FFAR3 (0.59) | FFAR3TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL10381001 | 0.94 | FFAR3 (0.67) | FFAR3TSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL10381000 | 0.94 | FFAR3 (0.67) | FFAR3TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL8175608 | 0.86 | FFAR3 (0.56) | FFAR3TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL28692592 | 0.86 | FFAR3 (0.56) | FFAR3TSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL8175601 | 0.86 | FFAR3 (0.56) | FFAR3TSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL8032158 | 0.84 | TSHR (0.75) | FFAR3TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL289218 | 0.84 | TSHR (0.75) | FFAR3TSHRTP53EGLN1EGLN3 | |
| Propionic Acid SCHEMBL2461940 | 0.84 | FFAR3 (0.83) | FFAR3TSHREGLN1TDP1ALDH1A1 | |
| Propionic Acid SCHEMBL4328390 | 0.84 | FFAR3 (0.83) | FFAR3TSHREGLN1TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985951-A | PHOTOPOLYMERIZABLE COMPOSITION FOR COSMETIC NAIL COATINGS WITH CELLULOSE ESTER OR TRANSESTER, PHOTOINITIATORS AND ETHYLENICALLY UNSATURATED CROSSLINKING AGENTS, EXPOSURE TO ACTINIC RADIATION TO FORM SOLVENT RESISTANT COATING | EASTMAN CHEMICAL COMPANY (US) | 1999-11-16 | — | — | US | disclosed |
| WO-1998048769-A1 | UV-CURABLE NAIL COATING FORMULATIONS CONTAINING CELLULOSE ESTERS WITH ETHYLENICALLY UNSATURATED PENDANT GROUPS | EASTMAN CHEMICAL COMPANY (US) | 1998-11-05 | — | — | WO | disclosed |
| EP-0409930-B1 | PROCESS FOR FORMING ANTI-HALATION LAYERS ON POLYESTER PHOTOGRAPHIC FILM SUPPORTS | EASTMAN KODAK CO (US) | 1995-03-08 | — | — | EP | disclosed |
| US-4914011-A | POLYETHYLENE TEREPHTHALATE, CARBON BLACK AND CELLULOSE ACETATE HEXA HYDROPHTHALATE | EASTMAN KODAK COMPANY (US) | 1990-04-03 | — | — | US | disclosed |