Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 16/20 | 0.58 |
| ▸ | DRD2 | P14416 | 14/20 | 0.58 |
| ▸ | HTR2A | P28223 | 14/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8439946 | 0.89 | HTR1A (0.56) | HTR1ADRD2HTR2ASLC6A4SLC6A2 | |
| SCHEMBL8439044 | 0.89 | HTR1A (0.56) | HTR1ADRD2HTR2ASLC6A4SLC6A2 | |
| SCHEMBL8420409 | 0.87 | HTR1A (0.57) | HTR1ADRD2HTR2ASLC6A4SLC6A2 | |
| SCHEMBL466903 | 0.80 | DRD2 (0.57) | HTR1ADRD2HTR2ASLC6A4DRD4 | |
| SCHEMBL5474121 | 0.79 | HTR1A (0.69) | HTR1ADRD2HTR2ASLC6A4SLC6A2 | |
| SCHEMBL8300540 | 0.78 | HTR1A (0.56) | HTR1ADRD2HTR2ASLC6A4SLC6A2 | |
| SCHEMBL2234606 | 0.78 | MAOA (0.44) | HTR1ADRD2HTR2ASLC6A4DRD4 | |
| SCHEMBL14560259 | 0.76 | HTR1A (0.63) | HTR1ADRD2HTR2ASLC6A4SLC6A2 | |
| SCHEMBL7364603 | 0.76 | CA12 (0.58) | HTR1ADRD2HTR2ASLC6A4SLC6A2 | |
| Hydrochloric Acid SCHEMBL10837761 | 0.75 | DRD2 (0.61) | HTR1ADRD2HTR2ASLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0848707-B1 | 4-(CYCLOALKYL)PIPERIDINES AND 4-(CYCLOALKYLALKYL)-PIPERIDINES DERIVATIVES, PREPARATION THEREOF AND THERAPEUTICAL APPLICATIONS THEREOF | SYNTHELABO (FR) | 1999-08-04 | — | — | EP | disclosed |
| CN-1201453-A | 4- (cycloalkyl) -piperidine and 4- (cycloalkylalkyl) piperidine derivatives, their preparation and their use in medicine | SYNTHELABO CO (FR) | 1998-12-09 | — | — | CN | disclosed |