Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 11/20 | 0.56 |
| ▸ | DRD2 | P14416 | 8/20 | 0.56 |
| ▸ | HTR2A | P28223 | 8/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8439946 | 0.90 | HTR1A (0.56) | HTR1ADRD2HTR2AADRA1DADRA1A | |
| SCHEMBL14560259 | 0.85 | HTR1A (0.63) | HTR1ADRD2HTR2AADRA1DADRA1A | |
| SCHEMBL14560260 | 0.84 | HTR1A (0.64) | HTR1ADRD2HTR2AADRA1DADRA1A | |
| SCHEMBL8439044 | 0.83 | HTR1A (0.56) | HTR1ADRD2HTR2AADRA1DADRA1A | |
| SCHEMBL8420409 | 0.82 | HTR1A (0.57) | HTR1ADRD2HTR2AADRA1DADRA1A | |
| SCHEMBL6403949 | 0.78 | HTR1A (0.60) | HTR1ADRD2HTR2AADRA1DADRA1A | |
| SCHEMBL8409485 | 0.78 | HTR1A (0.58) | HTR1ADRD2HTR2AADRA1DADRA1A | |
| SCHEMBL8302305 | 0.78 | GRIN2B (0.52) | HTR1ADRD2HTR2AEPHX2ACHE | |
| SCHEMBL8301786 | 0.77 | HTR1A (0.53) | HTR1ADRD2HTR2AGRIN1EPHX2 | |
| SCHEMBL466903 | 0.77 | DRD2 (0.57) | HTR1ADRD2HTR2ASLC6A4BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0848707-B1 | 4-(CYCLOALKYL)PIPERIDINES AND 4-(CYCLOALKYLALKYL)-PIPERIDINES DERIVATIVES, PREPARATION THEREOF AND THERAPEUTICAL APPLICATIONS THEREOF | SYNTHELABO (FR) | 1999-08-04 | — | — | EP | disclosed |