Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16166305 | 0.91 | SMN1; SMN2 (0.52) | SMN1; SMN2NAPRTGRM4RAB9AL3MBTL1 | |
| SCHEMBL1985578 | 0.87 | NAPRT (0.64) | SMN1; SMN2NAPRTGRM4RAB9AL3MBTL1 | |
| SCHEMBL12728201 | 0.85 | DGAT1 (0.59) | SMN1; SMN2NAPRTGRM4RAB9AL3MBTL1 | |
| SCHEMBL4895540 | 0.83 | MAPT (0.43) | SMN1; SMN2L3MBTL1ALDH1A1MAPTMEN1 | |
| SCHEMBL15979648 | 0.81 | NAPRT (0.53) | SMN1; SMN2NAPRTGRM4RAB9AL3MBTL1 | |
| SCHEMBL6622769 | 0.80 | SMN1; SMN2 (0.67) | SMN1; SMN2RAB9AL3MBTL1ALDH1A1MAPT | |
| SCHEMBL11899972 | 0.80 | NAPRT (0.56) | SMN1; SMN2NAPRTGRM4RAB9AL3MBTL1 | |
| SCHEMBL9263357 | 0.78 | KMT2A (0.60) | SMN1; SMN2RAB9AL3MBTL1ALDH1A1MAPT | |
| SCHEMBL20372049 | 0.78 | HSD17B3 (0.54) | NAPRTGRM4RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL3173315 | 0.77 | DGAT1 (0.60) | SMN1; SMN2NAPRTGRM4RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2984089-B1 | SUBSTITUTED PYRIMIDINIUM COMPOUNDS AND DERIVATIVES FOR COMBATING ANIMAL PESTS | BASF SE (DE) | 2022-03-09 | — | — | EP | disclosed |
| US-11019820-B2 | Substituted pyrimidinium compounds and derivatives for combating animal pests | BASF SE (DE) | 2021-06-01 | — | — | US | disclosed |
| US-20180007905-A1 | Substituted Pyrimidinium Compounds and Derivatives for Combating Animal Pests | BASF SE (DE) | 2018-01-11 | — | — | US | disclosed |
| US-9730451-B2 | Substituted pyrimidinium compounds and derivatives for combating animal pests | BASF SE (DE) | 2017-08-15 | — | — | US | disclosed |
| US-20160058009-A1 | Substituted Pyrimidinium Compounds and Derivatives for Combating Animal Pests | BASF SE (DE) | 2016-03-03 | — | — | US | disclosed |
| EP-2984089-A1 | SUBSTITUTED PYRIMIDINIUM COMPOUNDS AND DERIVATIVES FOR COMBATING ANIMAL PESTS | BASF SE (DE) | 2016-02-17 | — | — | EP | disclosed |
| WO-2014167084-A1 | SUBSTITUTED PYRIMIDINIUM COMPOUNDS AND DERIVATIVES FOR COMBATING ANIMAL PESTS | BASF SE (DE) | 2014-10-16 | — | — | WO | disclosed |
| US-5994540-A | HYDROXY- AND CHLORO-PYRIDYLPYRIDAZINONE DERIVATIVES | LONZA, LTD. (CH) | 1999-11-30 | — | — | US | disclosed |
| US-5760236-A | CHEMICAL INTERMEDIATES FOR PHARMACEUTICALS | LONZA, LTD. (CH) | 1998-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160058009-A1 | Substituted Pyrimidinium Compounds and Derivatives for Combating Animal Pests | THOP1, PRDX2, PRDX1 | SMN1; SMN2 1373/4885NAPRT 446/4885GRM4 671/4885 |
| US-11019820-B2 | Substituted pyrimidinium compounds and derivatives for combating animal pests | THOP1, PRDX2, PRDX1 | SMN1; SMN2 1373/4885NAPRT 446/4885GRM4 671/4885 |
| US-20180007905-A1 | Substituted Pyrimidinium Compounds and Derivatives for Combating Animal Pests | THOP1, PRDX2, PRDX1 | SMN1; SMN2 1373/4885NAPRT 446/4885GRM4 671/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.