Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.47 |
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10592602 | 0.81 | SIGMAR1 (0.49) | SIGMAR1GBA1HRH1SLC6A2SLC6A4 | |
| SCHEMBL4923835 | 0.77 | TAAR1 (0.43) | SIGMAR1GBA1HRH1SLC6A2SLC6A4 | |
| SCHEMBL22850604 | 0.76 | GBA1 (0.50) | SIGMAR1GBA1HRH1SLC6A2SLC6A4 | |
| SCHEMBL11451845 | 0.75 | GBA1 (0.53) | SIGMAR1GBA1HRH1SLC6A2SLC6A4 | |
| SCHEMBL1506033 | 0.74 | SOS1 (0.43) | SLC6A2SLC6A4SOS1 | |
| SCHEMBL8644471 | 0.73 | GBA1 (0.44) | SIGMAR1GBA1HRH1SLC6A2SLC6A4 | |
| SCHEMBL7304914 | 0.72 | GBA1 (0.50) | SIGMAR1GBA1HRH1SLC6A2SLC6A4 | |
| SCHEMBL27478385 | 0.72 | DPP4 (0.51) | SIGMAR1GBA1HRH1SLC6A2SLC6A4 | |
| SCHEMBL15265050 | 0.72 | GBA1 (0.50) | SIGMAR1GBA1HRH1SLC6A2SLC6A4 | |
| SCHEMBL16056164 | 0.72 | SLC6A2 (0.47) | GBA1HRH1SLC6A2SLC6A4SOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5866589-A | Alkyl substituted piperadinyl and piperazinyl anti-AIDS compounds | PHARMACIA & UPJOHN COMPANY (US) | 1999-02-02 | — | — | US | disclosed |